符合减肥手术条件的英国人群的模拟体重减轻:一项回顾性开放队列研究。

IF 3.4 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Dimitri J Pournaras, João Diogo da Rocha Fernandes, Sara Holloway, Alistair Marsland, Abd A Tahrani, Silvia Capucci
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引用次数: 0

摘要

在这项研究中,我们的目的是量化有限获得肥胖治疗的经济后果,并估计在符合减肥手术条件的人群中模拟体重减轻的效果。方法:这是一项回顾性开放队列研究,数据来自Discover数据库(2010年1月1日至2019年12月31日)。指数是指患者年龄≥18岁并符合减肥手术条件的第一天[体重指数(BMI)≥40.0 kg/m2(肥胖III类),或35.0-39.9 kg/m2(肥胖II类)和肥胖相关并发症]。评估了手术时间、医疗费用以及2年内模拟减肥对估计医疗费用的影响。结果:总共有137,184人符合减肥手术的条件,其中3241人(2.4%)最终在随访期间接受了手术。接受手术的人比有资格接受手术的人稍微年轻一些,而且更有可能是女性和白人。总体而言,36.6%的患者在获得资格后≥4年接受了手术。在这一组患者中,在手术前1年至8年期间,人均年医疗保健费用增加了75%[从1150英镑(GBP)到2013英镑]。模拟减肥10%将导致58.3%的符合条件的个体在2年后转变为I级肥胖,只有12.2%的人仍然是III级肥胖,导致医疗费用减少14.3%。更大程度的体重减轻与更大程度的BMI和成本降低相关。结论:延迟及时获得体重管理支持似乎与医疗费用增加有关,这可以通过改善获得体重管理来减轻。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Modelled Weight Loss in an English Population Eligible for Bariatric Surgery: A Retrospective Open Cohort Study.

Introduction: In this study, we aimed to quantify the economic consequences of limited access to obesity treatment and estimate the effect of modelled weight loss in a population who were eligible for bariatric surgery.

Methods: This was a retrospective open cohort study using data from the Discover database (1 January 2010-31 December 2019). Index was the first day that individuals were aged ≥ 18 years and eligible for bariatric surgery [body mass index (BMI) ≥ 40.0 kg/m2 (obesity class III), or 35.0-39.9 kg/m2 (obesity class II) and an obesity-related complication]. Time to surgery, healthcare costs and the impact of modelled weight loss over 2 years on estimated healthcare costs were assessed.

Results: In total, 137,184 individuals were eligible for bariatric surgery, of whom 3241 (2.4%) ultimately received surgery during follow-up. Individuals who received surgery were slightly younger, and were more likely to be women and white, than the population eligible for surgery. Overall, 36.6% of individuals underwent surgery ≥ 4 years after they became eligible. Mean annual per-person healthcare costs increased 75% between year 1 and year 8 of the period before surgery in this group [from 1150 British pound sterling (GBP) to 2013 GBP]. Modelled weight loss of 10% would result in 58.3% of eligible individuals transitioning to obesity class I after 2 years, with only 12.2% remaining in obesity class III, resulting in a 14.3% reduction in healthcare costs. Greater degrees of weight loss were associated with greater estimated reductions in BMI and cost.

Conclusion: Delays to prompt weight management support appear to be associated with increasing healthcare costs, which could be mitigated by improving access to weight management.

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来源期刊
Advances in Therapy
Advances in Therapy 医学-药学
CiteScore
7.20
自引率
2.60%
发文量
353
审稿时长
6-12 weeks
期刊介绍: Advances in Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Advances in Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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