Akram Alghamdi, Muhammad Nadir Naqqash, Nimra Batool, Muhammad Asif Farooq, Ahmed Noureldeen, Hadeer Darwish, Attalla F El-Kott, Salama A Salama, Yasser Rabea Elmarassi
{"title":"肉桂提取物对家蝇亚致死效应及分子反应。","authors":"Akram Alghamdi, Muhammad Nadir Naqqash, Nimra Batool, Muhammad Asif Farooq, Ahmed Noureldeen, Hadeer Darwish, Attalla F El-Kott, Salama A Salama, Yasser Rabea Elmarassi","doi":"10.1007/s00114-025-01998-w","DOIUrl":null,"url":null,"abstract":"<p><p>The house fly, Musca domestica L., plays a crucial role as a mechanical vector for a variety of pathogens that impact both humans and animals, highlighting the need for effective control measures. Conventional approaches, including sanitation and waste management, exhibit certain constraints, resulting in a dependence on synthetic insecticides that carry potential risks of toxicity and the development of resistance. This research examined the lethal and behavioral effects of Cinnamomum verum (cinnamon) extracts on house flies, employing an age-stage two-sex life table methodology to evaluate life table parameters. The analysis utilizing gas chromatography-mass spectrometry (GC-MS) revealed significant phytochemicals present in cinnamon bark, such as cinnamaldehyde and eugenol, which are recognized for their insecticidal and behavioral effects in insects. Acute toxicity assessments demonstrated lethal concentrations (LC<sub>5</sub>, LC<sub>25</sub>, and control) of cinnamon extracts, significantly affecting developmental and reproductive parameters. Interestingly, lower concentrations (LC<sub>5</sub>) promoted fecundity and intrinsic growth rates compared to higher concentrations (LC<sub>25</sub>), suggesting a biphasic response that aligns with the concept of pesticide-induced hormesis. Furthermore, oviposition preference trials confirmed a concentration-dependent deterrent effect of cinnamon extracts, with higher doses significantly reducing egg-laying behavior in gravid females. This research has included traditional GC-MS-based phytochemical screening by incorporating comprehensive biological and molecular assessments, offering a more integrated approach for biopesticide identification. The identification of phytochemicals like cinnamaldehyde and α-muurolene establishes a robust basis for the screening of additional bioactive compounds and exploring novel insecticidal agents.</p>","PeriodicalId":794,"journal":{"name":"The Science of Nature","volume":"112 4","pages":"50"},"PeriodicalIF":2.1000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sublethal effect and molecular responses of Musca domestica to cinnamon extracts.\",\"authors\":\"Akram Alghamdi, Muhammad Nadir Naqqash, Nimra Batool, Muhammad Asif Farooq, Ahmed Noureldeen, Hadeer Darwish, Attalla F El-Kott, Salama A Salama, Yasser Rabea Elmarassi\",\"doi\":\"10.1007/s00114-025-01998-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The house fly, Musca domestica L., plays a crucial role as a mechanical vector for a variety of pathogens that impact both humans and animals, highlighting the need for effective control measures. Conventional approaches, including sanitation and waste management, exhibit certain constraints, resulting in a dependence on synthetic insecticides that carry potential risks of toxicity and the development of resistance. This research examined the lethal and behavioral effects of Cinnamomum verum (cinnamon) extracts on house flies, employing an age-stage two-sex life table methodology to evaluate life table parameters. The analysis utilizing gas chromatography-mass spectrometry (GC-MS) revealed significant phytochemicals present in cinnamon bark, such as cinnamaldehyde and eugenol, which are recognized for their insecticidal and behavioral effects in insects. Acute toxicity assessments demonstrated lethal concentrations (LC<sub>5</sub>, LC<sub>25</sub>, and control) of cinnamon extracts, significantly affecting developmental and reproductive parameters. Interestingly, lower concentrations (LC<sub>5</sub>) promoted fecundity and intrinsic growth rates compared to higher concentrations (LC<sub>25</sub>), suggesting a biphasic response that aligns with the concept of pesticide-induced hormesis. Furthermore, oviposition preference trials confirmed a concentration-dependent deterrent effect of cinnamon extracts, with higher doses significantly reducing egg-laying behavior in gravid females. This research has included traditional GC-MS-based phytochemical screening by incorporating comprehensive biological and molecular assessments, offering a more integrated approach for biopesticide identification. The identification of phytochemicals like cinnamaldehyde and α-muurolene establishes a robust basis for the screening of additional bioactive compounds and exploring novel insecticidal agents.</p>\",\"PeriodicalId\":794,\"journal\":{\"name\":\"The Science of Nature\",\"volume\":\"112 4\",\"pages\":\"50\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Science of Nature\",\"FirstCategoryId\":\"6\",\"ListUrlMain\":\"https://doi.org/10.1007/s00114-025-01998-w\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Science of Nature","FirstCategoryId":"6","ListUrlMain":"https://doi.org/10.1007/s00114-025-01998-w","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Sublethal effect and molecular responses of Musca domestica to cinnamon extracts.
The house fly, Musca domestica L., plays a crucial role as a mechanical vector for a variety of pathogens that impact both humans and animals, highlighting the need for effective control measures. Conventional approaches, including sanitation and waste management, exhibit certain constraints, resulting in a dependence on synthetic insecticides that carry potential risks of toxicity and the development of resistance. This research examined the lethal and behavioral effects of Cinnamomum verum (cinnamon) extracts on house flies, employing an age-stage two-sex life table methodology to evaluate life table parameters. The analysis utilizing gas chromatography-mass spectrometry (GC-MS) revealed significant phytochemicals present in cinnamon bark, such as cinnamaldehyde and eugenol, which are recognized for their insecticidal and behavioral effects in insects. Acute toxicity assessments demonstrated lethal concentrations (LC5, LC25, and control) of cinnamon extracts, significantly affecting developmental and reproductive parameters. Interestingly, lower concentrations (LC5) promoted fecundity and intrinsic growth rates compared to higher concentrations (LC25), suggesting a biphasic response that aligns with the concept of pesticide-induced hormesis. Furthermore, oviposition preference trials confirmed a concentration-dependent deterrent effect of cinnamon extracts, with higher doses significantly reducing egg-laying behavior in gravid females. This research has included traditional GC-MS-based phytochemical screening by incorporating comprehensive biological and molecular assessments, offering a more integrated approach for biopesticide identification. The identification of phytochemicals like cinnamaldehyde and α-muurolene establishes a robust basis for the screening of additional bioactive compounds and exploring novel insecticidal agents.
期刊介绍:
The Science of Nature - Naturwissenschaften - is Springer''s flagship multidisciplinary science journal. The journal is dedicated to the fast publication and global dissemination of high-quality research and invites papers, which are of interest to the broader community in the biological sciences. Contributions from the chemical, geological, and physical sciences are welcome if contributing to questions of general biological significance. Particularly welcomed are contributions that bridge between traditionally isolated areas and attempt to increase the conceptual understanding of systems and processes that demand an interdisciplinary approach.