肉桂提取物对家蝇亚致死效应及分子反应。

IF 2.1 3区 生物学 Q2 MULTIDISCIPLINARY SCIENCES
Akram Alghamdi, Muhammad Nadir Naqqash, Nimra Batool, Muhammad Asif Farooq, Ahmed Noureldeen, Hadeer Darwish, Attalla F El-Kott, Salama A Salama, Yasser Rabea Elmarassi
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引用次数: 0

摘要

家蝇(Musca domestica L.)作为影响人类和动物的多种病原体的机械媒介,发挥着至关重要的作用,因此需要采取有效的控制措施。包括环境卫生和废物管理在内的传统方法存在某些限制,导致对合成杀虫剂的依赖,而合成杀虫剂具有潜在的毒性和产生抗药性的风险。本研究采用年龄阶段两性生命表法对家蝇的生命表参数进行评价,考察了肉桂提取物对家蝇的致死性和行为性影响。通过气相色谱-质谱联用分析发现,肉桂皮中含有大量的植物化学物质,如肉桂醛和丁香酚,这些化学物质被认为对昆虫具有杀虫和行为作用。急性毒性评估表明,肉桂提取物的致死浓度(LC5、LC25和对照)显著影响发育和生殖参数。有趣的是,与高浓度(LC25)相比,低浓度(LC5)促进了繁殖力和内在生长率,这表明了一种与农药诱导激效概念一致的双相反应。此外,产卵偏好试验证实了肉桂提取物的浓度依赖性威慑作用,高剂量显著降低妊娠雌性的产卵行为。本研究将传统的gc - ms为基础的植物化学筛选纳入了综合的生物学和分子评估,为生物农药鉴定提供了更综合的方法。肉桂醛和α-茂林等植物化学物质的鉴定为筛选其他生物活性化合物和探索新型杀虫剂奠定了坚实的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sublethal effect and molecular responses of Musca domestica to cinnamon extracts.

The house fly, Musca domestica L., plays a crucial role as a mechanical vector for a variety of pathogens that impact both humans and animals, highlighting the need for effective control measures. Conventional approaches, including sanitation and waste management, exhibit certain constraints, resulting in a dependence on synthetic insecticides that carry potential risks of toxicity and the development of resistance. This research examined the lethal and behavioral effects of Cinnamomum verum (cinnamon) extracts on house flies, employing an age-stage two-sex life table methodology to evaluate life table parameters. The analysis utilizing gas chromatography-mass spectrometry (GC-MS) revealed significant phytochemicals present in cinnamon bark, such as cinnamaldehyde and eugenol, which are recognized for their insecticidal and behavioral effects in insects. Acute toxicity assessments demonstrated lethal concentrations (LC5, LC25, and control) of cinnamon extracts, significantly affecting developmental and reproductive parameters. Interestingly, lower concentrations (LC5) promoted fecundity and intrinsic growth rates compared to higher concentrations (LC25), suggesting a biphasic response that aligns with the concept of pesticide-induced hormesis. Furthermore, oviposition preference trials confirmed a concentration-dependent deterrent effect of cinnamon extracts, with higher doses significantly reducing egg-laying behavior in gravid females. This research has included traditional GC-MS-based phytochemical screening by incorporating comprehensive biological and molecular assessments, offering a more integrated approach for biopesticide identification. The identification of phytochemicals like cinnamaldehyde and α-muurolene establishes a robust basis for the screening of additional bioactive compounds and exploring novel insecticidal agents.

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来源期刊
The Science of Nature
The Science of Nature 综合性期刊-综合性期刊
CiteScore
3.40
自引率
0.00%
发文量
47
审稿时长
4-8 weeks
期刊介绍: The Science of Nature - Naturwissenschaften - is Springer''s flagship multidisciplinary science journal. The journal is dedicated to the fast publication and global dissemination of high-quality research and invites papers, which are of interest to the broader community in the biological sciences. Contributions from the chemical, geological, and physical sciences are welcome if contributing to questions of general biological significance. Particularly welcomed are contributions that bridge between traditionally isolated areas and attempt to increase the conceptual understanding of systems and processes that demand an interdisciplinary approach.
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