丹参素生物合成研究进展。

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-06-18 DOI:10.1002/cbic.202500402

Yuben Qiao, Ikuro Abe

引用次数: 0

摘要

Sordarin是一种结构独特的天然产物衍生抗真菌抗生素，靶向真核翻译延伸因子2 (eEF2)，近年来进行了广泛的生物合成表征。本文综述了在了解其生物合成方面的关键进展。这些见解为设计下一代抗真菌药物以解决新出现的耐药机制提供了关键途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Advances in the Biosynthetic Studies of Sordarin.

Sordarin, a structurally distinct natural product-derived antifungal antibiotic targeting eukaryotic translation elongation factor 2, has undergone extensive biosynthetic characterizations in recent studies. This review highlights key advances in understanding its biosynthesis. These insights offer critical pathways for designing next-generation antifungal agents to address emerging resistance mechanisms.

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).