Yang Liu, Fen Wan, Ruoyu Ba, Yimin Han, Ting Geng, Beihua Bao, Weifeng Yao, Wei-Wei Xiong, Li Zhang, Fang-Fang Cheng
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Ophicalcitum-Inspired Microspheres as a Topical Hemostatic Agent.
Ophicalcitum, as an oral mineral in traditional Chinese medicine, has a long history of therapeutic use in hemostasis, and its main component is calcium carbonate, which has good biosafety, excellent structural properties, and low cost. Inspired by it, calcium carbonate microspheres with different particle sizes were synthesized using ethylene glycol and ultrapure water as solvents. Furthermore, luteolin was loaded onto calcium carbonate microspheres to prepare multifunctional hemostatic materials with healing-promoting effects. Experimental results have shown that calcium carbonate microspheres had excellent hemostatic properties without hemolytic, cytotoxic, and metabolic toxic effects and their hemostatic properties were independent of particle sizes. In addition, luteolin loaded on calcium carbonate microspheres promoted skin healing, indicating that these calcium carbonate microspheres were potential hemostatic materials.
期刊介绍：
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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