{"title":"α-酮戊二酸靶向递送至骨巨噬细胞：改善2型糖尿病骨折愈合的新治疗策略（Sci. 23/2025）","authors":"Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng","doi":"10.1002/advs.202570178","DOIUrl":null,"url":null,"abstract":"<p><b>Improving Fracture Healing in Type 2 Diabetes</b></p><p>In article number 2415667, Jia Li, Wei Lei, Yafei Feng, and co-workers demonstrate that diminished α-ketoglutarate (α-KG) levels impair bone morphogenetic protein 2 (BMP2) secretion in macrophages under type 2 diabetes mellitus (T2DM) conditions. This cover illustration depicts the mechanism of alendronate-modified liposomes designed to specifically target macrophages and deliver α-KG payloads. Through epigenetic reprogramming mediated by α-KG supplementation, macrophages regain their ability to secrete BMP2, thereby promoting fracture healing processes. These findings establish targeted α-KG delivery to macrophages as a novel therapeutic strategy for improving impaired fracture healing in T2DM patients.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 23","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570178","citationCount":"0","resultStr":"{\"title\":\"Targeted Delivery of α-ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes (Adv. Sci. 23/2025)\",\"authors\":\"Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng\",\"doi\":\"10.1002/advs.202570178\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Improving Fracture Healing in Type 2 Diabetes</b></p><p>In article number 2415667, Jia Li, Wei Lei, Yafei Feng, and co-workers demonstrate that diminished α-ketoglutarate (α-KG) levels impair bone morphogenetic protein 2 (BMP2) secretion in macrophages under type 2 diabetes mellitus (T2DM) conditions. This cover illustration depicts the mechanism of alendronate-modified liposomes designed to specifically target macrophages and deliver α-KG payloads. Through epigenetic reprogramming mediated by α-KG supplementation, macrophages regain their ability to secrete BMP2, thereby promoting fracture healing processes. These findings establish targeted α-KG delivery to macrophages as a novel therapeutic strategy for improving impaired fracture healing in T2DM patients.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":117,\"journal\":{\"name\":\"Advanced Science\",\"volume\":\"12 23\",\"pages\":\"\"},\"PeriodicalIF\":14.1000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570178\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Science\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570178\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570178","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Targeted Delivery of α-ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes (Adv. Sci. 23/2025)
Improving Fracture Healing in Type 2 Diabetes
In article number 2415667, Jia Li, Wei Lei, Yafei Feng, and co-workers demonstrate that diminished α-ketoglutarate (α-KG) levels impair bone morphogenetic protein 2 (BMP2) secretion in macrophages under type 2 diabetes mellitus (T2DM) conditions. This cover illustration depicts the mechanism of alendronate-modified liposomes designed to specifically target macrophages and deliver α-KG payloads. Through epigenetic reprogramming mediated by α-KG supplementation, macrophages regain their ability to secrete BMP2, thereby promoting fracture healing processes. These findings establish targeted α-KG delivery to macrophages as a novel therapeutic strategy for improving impaired fracture healing in T2DM patients.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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