探索降低甲基苯丙胺使用障碍患者药物渴望的后检索策略

IF 2.6 3区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Junjiao Li, Yuanyuan Dong, Wei Chen, Jian Wang, Xifu Zheng
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引用次数: 0

摘要

基于记忆再巩固的提取后干预在减少成瘾相关记忆方面显示出了希望。然而,对甲基苯丙胺(MA)使用的研究,特别是对人类的研究仍然有限。本研究旨在评估一种复原后干预模式在管理甲基苯丙胺使用障碍(MUD)中的效果,研究对象为来自某强制戒毒中心的46名个体。采用单盲设计,将参与者随机分为三组:(1)检索-无干预,(2)检索-灭绝和(3)检索-认知任务。该研究包括基线测试,随后使用MA线索进行记忆检索,并在记忆再巩固窗口期间进行三种干预中的一种。干预措施为:(1)检索后不再干预;(2)消去训练;(3)记忆再激活后玩俄罗斯方块。通过生理和心理指标评估复发,重点关注自发性和线索诱导的MUD记忆复发。结果表明,与单独检索相比,检索-灭绝和检索-认知任务在减少对MUD的渴望和预防复发方面都有好处。MA记忆复发的生理、心理指标相关性较弱,且在多个维度上存在差异。这些发现提示了MUD干预的新策略,并为临床治疗提供了有价值的见解。本文还讨论了本研究的局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring Post-Retrieval Strategies to Reduce Drug Craving in Methamphetamine Use Disorders

Exploring Post-Retrieval Strategies to Reduce Drug Craving in Methamphetamine Use Disorders

Post-retrieval interventions based on memory reconsolidation have shown promise in reducing addiction-related memories. However, research on methamphetamine (MA) use, particularly in humans, remains limited. This study aimed to evaluate the efficacy of a post-retrieval intervention paradigm in managing methamphetamine use disorder (MUD) with 46 individuals from a compulsory drug rehabilitation centre. A single-blind design was employed, with participants randomly assigned to one of three groups: (1) retrieval–no intervention, (2) retrieval–extinction and (3) retrieval–cognitive task. The study involved baseline testing, followed by memory retrieval using MA cues, and one of the three interventions during the memory reconsolidation window. The interventions were as follows: (1) no further intervention after retrieval, (2) extinction training and (3) playing Tetris after memory reactivation. Relapse was assessed through physiological and psychological indicators, with a focus on both spontaneous and cue-induced relapse of MUD memory. The results showed that both retrieval–extinction and retrieval–cognitive task showed benefits in reducing cravings and preventing relapse in MUD compared to retrieval alone. Physiological and psychological indicators of MA memory relapse showed weak correlation and differed across several dimensions. These findings suggest new strategies for MUD intervention and provide valuable insights for clinical treatment. Limitations of the study are also discussed.

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来源期刊
Addiction Biology
Addiction Biology 生物-生化与分子生物学
CiteScore
8.10
自引率
2.90%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Addiction Biology is focused on neuroscience contributions and it aims to advance our understanding of the action of drugs of abuse and addictive processes. Papers are accepted in both animal experimentation or clinical research. The content is geared towards behavioral, molecular, genetic, biochemical, neuro-biological and pharmacology aspects of these fields. Addiction Biology includes peer-reviewed original research reports and reviews. Addiction Biology is published on behalf of the Society for the Study of Addiction to Alcohol and other Drugs (SSA). Members of the Society for the Study of Addiction receive the Journal as part of their annual membership subscription.
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