振兴天然产品的可持续药物发现：创新连接食品生物科学和绿色治疗发展

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy Pub Date : 2025-06-20 DOI:10.1016/j.scp.2025.102082

Ramachandran Chelliah , Selvakumar Vijayalakshmi , Murugan Karuvelan , Kaliyan Barathikannan , Sulav Ghimeray , Deog-Hwan Oh

{"title":"振兴天然产品的可持续药物发现：创新连接食品生物科学和绿色治疗发展","authors":"Ramachandran Chelliah , Selvakumar Vijayalakshmi , Murugan Karuvelan , Kaliyan Barathikannan , Sulav Ghimeray , Deog-Hwan Oh","doi":"10.1016/j.scp.2025.102082","DOIUrl":null,"url":null,"abstract":"<div><div>Natural products (NPs) and their derivatives have long served as essential sources of therapeutic agents, addressing global health challenges from cancer and infection to chronic metabolic diseases. Although interest in NP research had declined due to challenges in screening, characterization, and sustainable sourcing, recent breakthroughs in genomics, synthetic biology, metabolomics, and artificial intelligence (AI) have reinvigorated this field. This review presents an interdisciplinary framework that unites food bioscience, pharmacognosy, and green chemistry to advance sustainable NP-based drug discovery. Food bioscience contributes innovations such as foodomics, microbial fermentation, and waste biomass valorization. Pharmacognosy offers insights from ethnobotanical knowledge, chemo-taxonomy, and bioactivity-guided isolation, while green chemistry enables the adoption of eco-friendly solvents, biocatalysis, and scalable clean synthesis. Together, these domains support a systems-level approach to responsible resource extraction, bioactive characterization, and environment-safe therapeutic development. By aligning with the 12 Principles of Green Chemistry and UN Sustainable Development Goals (SDGs), we propose a unified roadmap for accelerating drug discovery while minimizing ecological impact and promoting social equity.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102082"},"PeriodicalIF":5.8000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Revitalizing natural products for sustainable drug Discovery: Innovations bridging food bioscience and green therapeutic development\",\"authors\":\"Ramachandran Chelliah , Selvakumar Vijayalakshmi , Murugan Karuvelan , Kaliyan Barathikannan , Sulav Ghimeray , Deog-Hwan Oh\",\"doi\":\"10.1016/j.scp.2025.102082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Natural products (NPs) and their derivatives have long served as essential sources of therapeutic agents, addressing global health challenges from cancer and infection to chronic metabolic diseases. Although interest in NP research had declined due to challenges in screening, characterization, and sustainable sourcing, recent breakthroughs in genomics, synthetic biology, metabolomics, and artificial intelligence (AI) have reinvigorated this field. This review presents an interdisciplinary framework that unites food bioscience, pharmacognosy, and green chemistry to advance sustainable NP-based drug discovery. Food bioscience contributes innovations such as foodomics, microbial fermentation, and waste biomass valorization. Pharmacognosy offers insights from ethnobotanical knowledge, chemo-taxonomy, and bioactivity-guided isolation, while green chemistry enables the adoption of eco-friendly solvents, biocatalysis, and scalable clean synthesis. Together, these domains support a systems-level approach to responsible resource extraction, bioactive characterization, and environment-safe therapeutic development. By aligning with the 12 Principles of Green Chemistry and UN Sustainable Development Goals (SDGs), we propose a unified roadmap for accelerating drug discovery while minimizing ecological impact and promoting social equity.</div></div>\",\"PeriodicalId\":22138,\"journal\":{\"name\":\"Sustainable Chemistry and Pharmacy\",\"volume\":\"46 \",\"pages\":\"Article 102082\"},\"PeriodicalIF\":5.8000,\"publicationDate\":\"2025-06-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sustainable Chemistry and Pharmacy\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352554125001809\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sustainable Chemistry and Pharmacy","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352554125001809","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

天然产物及其衍生物长期以来一直是治疗剂的重要来源，解决了从癌症和感染到慢性代谢性疾病的全球健康挑战。尽管由于筛选、表征和可持续来源方面的挑战，对NP研究的兴趣有所下降，但最近基因组学、合成生物学、代谢组学和人工智能（AI）方面的突破使这一领域重新焕发活力。这篇综述提出了一个跨学科的框架，将食品生物科学，生药学和绿色化学结合起来，以促进可持续的基于np的药物发现。食品生物科学有助于食品组学、微生物发酵和废物生物质增值等创新。生药学提供了民族植物学知识，化学分类学和生物活性引导分离的见解，而绿色化学使采用环保溶剂，生物催化和可扩展的清洁合成成为可能。这些领域共同支持负责任的资源提取、生物活性表征和环境安全治疗开发的系统级方法。通过与绿色化学12项原则和联合国可持续发展目标（sdg）保持一致，我们提出了一个统一的路线图，以加速药物发现，同时最大限度地减少生态影响和促进社会公平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Revitalizing natural products for sustainable drug Discovery: Innovations bridging food bioscience and green therapeutic development

查看原文本刊更多论文

Revitalizing natural products for sustainable drug Discovery: Innovations bridging food bioscience and green therapeutic development

Natural products (NPs) and their derivatives have long served as essential sources of therapeutic agents, addressing global health challenges from cancer and infection to chronic metabolic diseases. Although interest in NP research had declined due to challenges in screening, characterization, and sustainable sourcing, recent breakthroughs in genomics, synthetic biology, metabolomics, and artificial intelligence (AI) have reinvigorated this field. This review presents an interdisciplinary framework that unites food bioscience, pharmacognosy, and green chemistry to advance sustainable NP-based drug discovery. Food bioscience contributes innovations such as foodomics, microbial fermentation, and waste biomass valorization. Pharmacognosy offers insights from ethnobotanical knowledge, chemo-taxonomy, and bioactivity-guided isolation, while green chemistry enables the adoption of eco-friendly solvents, biocatalysis, and scalable clean synthesis. Together, these domains support a systems-level approach to responsible resource extraction, bioactive characterization, and environment-safe therapeutic development. By aligning with the 12 Principles of Green Chemistry and UN Sustainable Development Goals (SDGs), we propose a unified roadmap for accelerating drug discovery while minimizing ecological impact and promoting social equity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Sustainable Chemistry and Pharmacy Environmental Science-Pollution

CiteScore

8.20

自引率

6.70%

发文量

274

审稿时长

37 days

期刊介绍： Sustainable Chemistry and Pharmacy publishes research that is related to chemistry, pharmacy and sustainability science in a forward oriented manner. It provides a unique forum for the publication of innovative research on the intersection and overlap of chemistry and pharmacy on the one hand and sustainability on the other hand. This includes contributions related to increasing sustainability of chemistry and pharmaceutical science and industries itself as well as their products in relation to the contribution of these to sustainability itself. As an interdisciplinary and transdisciplinary journal it addresses all sustainability related issues along the life cycle of chemical and pharmaceutical products form resource related topics until the end of life of products. This includes not only natural science based approaches and issues but also from humanities, social science and economics as far as they are dealing with sustainability related to chemistry and pharmacy. Sustainable Chemistry and Pharmacy aims at bridging between disciplines as well as developing and developed countries.