序贯放射合成方法：二醇树脂上硼酯前体的组装和铜介导的放射性碘波化和叠氮化物-炔环加成的放射性碘化

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-06-09 DOI:10.1021/acs.joc.5c0038210.1021/acs.joc.5c00382

Yuto Kondo, Hiroyuki Kimura*, Mamiko Tanaka, Yasunao Hattori, Hidekazu Kawashima, Kazuhiro Takahashi and Hiroyuki Yasui,

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引用次数: 0

摘要

流线型放射性合成方法使硼酯前体在二醇树脂上的精确顺序组装成为可能，无缝整合铜介导的放射性碘波化和叠氮化物-炔环加成。这种方法产生具有高放射化学转化率（>90%）的放射性碘化化合物，直到最后阶段才需要柱纯化，从而加速了先进放射性碘化分子探针的有效开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Sequential Radiosynthetic Methodology: Assembly of Boronic Ester Precursors on a Diol Resin and Radioiodination Using Copper-Mediated Radioiododeboronation and Azide–Alkyne Cycloaddition

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Sequential Radiosynthetic Methodology: Assembly of Boronic Ester Precursors on a Diol Resin and Radioiodination Using Copper-Mediated Radioiododeboronation and Azide–Alkyne Cycloaddition

A streamlined radiosynthetic methodology enables the precise sequential assembly of boronic ester precursors on diol resin, seamlessly integrating copper-mediated radioiododeboronation and azide–alkyne cycloaddition. This approach yields radioiodinated compounds with high radiochemical conversion (>90%) without requiring column purification until the final stage, thereby accelerating the efficient development of advanced radioiodinated molecular probes.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.