影像学进展检测帕金森病的非运动性前驱标志物并探索治疗转化机会

IF 6.7 1区医学 Q1 NEUROSCIENCES

NPJ Parkinson's Disease Pub Date : 2025-06-18 DOI:10.1038/s41531-025-01004-0

Mathangi Palanivel, Krishna Kanta Ghosh, Madhav Mallam, Raghavan Bhuvanakantham, Parasuraman Padmanabhan, Kah-Leong Lim, Balázs Gulyás

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引用次数: 0

摘要

帕金森病（PD）是一种进行性神经系统疾病，以晚期出现的运动症状为特征，但早期的非运动症状，如睡眠不足和快速眼动睡眠行为障碍，可能比诊断早几年。在前驱阶段识别非运动生物标志物可以预测表型转化并进行早期干预。本文概述了主要的前驱非运动症状，总结了早期检测的成像技术，并探讨了它们在指导高危个体及时的神经保护治疗方面的转化潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities

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Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities

Parkinson’s disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years. Identifying non-motor biomarkers during this prodromal phase could predict phenoconversion and enable early interventions. This narrative review outlines key prodromal non-motor symptoms, summarizes imaging technologies for early detection, and explores their translational potential in guiding timely, neuroprotective therapies for at-risk individuals.

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来源期刊

NPJ Parkinson's Disease Medicine-Neurology (clinical)

CiteScore

9.80

自引率

5.70%

发文量

156

审稿时长

11 weeks

期刊介绍： npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.