在两年的随访中，认知能力未受损个体的阿尔茨海默病病理生物标志物与认知能力下降无关。

IF 1.5 4区心理学 Q4 CLINICAL NEUROLOGY

Applied Neuropsychology-Adult Pub Date : 2025-06-17 DOI:10.1080/23279095.2025.2518566

Ingvild Vøllo Eliassen, Bjørn-Eivind Kirsebom, Knut Waterloo, Ragnhild Eide Skogseth, Gøril Rolfseng Grøntvedt, Mathilde Suhr Hemminghyth, Berglind Gísladóttir, Fernando Gonzalez-Ortiz, Dag Aarsland, Tormod Fladby, Erik Hessen

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引用次数: 0

摘要

背景：阿尔茨海默病（AD）病理可能存在于认知未受损的个体中，但其临床意义尚不清楚。细微的认知能力下降是临床前AD的潜在标志。目的：探讨ad相关脑脊液（Aβ42/40, p-tau, t-tau, NfL）或血浆（p217, BD-tau, NfL）生物标志物病理学对基线认知功能未受损个体两年认知变化评分的影响。方法：参与者为148名认知功能正常的老年人（平均年龄为68.11岁）。两年内的平均认知变化在正常和病理生物标志物状态的参与者之间分别进行比较。结果：我们发现生物标志物值异常的人群与正常生物标志物组相比，平均变化评分无显著差异。结论：无论基线脑脊液生物标志物阳性与否，该组未观察到明显的认知变化。

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Pathological biomarkers for Alzheimer's disease in cognitively unimpaired individuals are not associated with cognitive decline at two-year follow-up.

Background: Alzheimer's disease (AD) pathology may be present in cognitively unimpaired individuals, but the clinical implications of this are unclear. Subtle cognitive decline is a potential marker of preclinical AD.

Objective: To investigate whether two-year cognitive change scores are influenced by AD-linked cerebrospinal fluid (Aβ_42/40, p-tau, t-tau, NfL) or plasma (p217, BD-tau, NfL) biomarker pathology in individuals who are cognitively unimpaired at baseline.

Methods: Participants were 148 cognitively unimpaired older adults (mean age = 68.11). Mean cognitive change over two years was compared between participants with normal and pathological biomarker status, for each biomarker separately.

Results: We found no significant difference between mean change scores in people with abnormal biomarker values compared to normal biomarker groups.

Conclusion: Regardless of baseline CSF biomarker positivity, no significant cognitive change was observed in this group.

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来源期刊

Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY

CiteScore

4.50

自引率

11.80%

发文量

134

期刊介绍： pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.