THE RELATIONSHIP BETWEEN POTENTIAL DIET INFLAMMATORY LOAD AND CHEMERIN, ANDROGENS AND INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME.

Background: In recent years, the effect of inflammation on the pathophysiology of polycystic ovary syndrome (PCOS) has attracted considerable attention. However, the effect of the dietary inflammatory load remains unclear.

Objective: This study was conducted to evaluate the relationship between dietary inflammatory index (DII) score and serum chemerin concentration, biochemical hyperandrogenism and insulin resistance in women with PCOS.

Methods: This study, which is a case-control study, was conducted on 44 women with PCOS and 44 healthy women who applied to Ankara Training and Research Hospital. Routine blood biochemical values were obtained from the hospital system and blood samples were taken for serum chemerin analysis. The questionnaire investigated the general information, physical activity status, and anthropometric measurements. The DII was calculated from three-day dietary records.

Results: The mean DII score of the in the PCOS and control groups is 3.8 ± 1.7 and 3.8 ± 1.4, respectively (p> 0.05). Serum chemerin concentration (3.6 ± 1.4 ng / mL) of the women in the PCOS group with a high DII score was significantly higher than the women in the control group (2.6 ± 1.7 ng / mL) (p <0.05). There was no statistically significant difference between DII score and insulin resistance, total and free testosterone, DHEA-S, LH, FSH, LH/FSH ratio and estradiol values (p>0.05).

Conclusions: The highest serum chemerin concentrations was found in the PCOS group with the highest DII. Results suggest that an inflammatory diet may be associated with serum chemerin concentration in PCOS.