真核mrna 3'非翻译区研究进展。

Q3 Medicine

遗传 Pub Date : 2025-06-01 DOI:10.16288/j.yczz.24-283

Hao-Yu Luo, Xiao-Hong Yan, Fang Mu, Ning Wang

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引用次数: 0

摘要

3′非翻译区（3′untranslationregions, utrs）是真核信使rna （mrna）的一个组成部分，位于mrna的3′端。3' utr在转录后调控基因表达、调控裂解和聚腺苷化、mRNA稳定性、mRNA翻译和定位等方面发挥着至关重要的作用。随着对3’utr研究的不断深入，以及各种组学方法的出现，人们发现了真核生物3’utr的一些意想不到的功能。本文就3’utrs的研究进展进行综述，并对未来3’utrs的作用和机制的研究方向进行展望，以期为全面研究基因功能和调控提供更好的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent advances in the study of 3' untranslated regions of eukaryotic mRNAs.

The 3' untranslated regions (3'UTRs) are a component of eukaryotic messenger RNAs (mRNAs) and located at their 3'-most ends. 3'UTRs play crucial roles in post-transcriptional regulation of gene expression, regulating cleavage and polyadenylation, mRNA stability, mRNA translation and localization. With deepening research of the 3'UTRs, and with advent of various omics methods, a few unexpected functions of the eukaryotic 3'UTRs have been uncovered. In this review, we summarize recent advances in the study of 3'UTRs and propose the future research directions for studying the roles and mechanisms of the 3'UTRs, with the aim to provide a better reference for comprehensively investigating gene function and regulation.

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来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.