Daria I Zhigalina, Evgeny V Denisov, Igor N Lebedev, Nikolay A Skryabin
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Embryoid bodies as a model system for exploring early human embryonic development.
This review article aims to summarize the existing concepts related to embryoid bodies (EBs) and explore their potential as a model system for studying various aspects of human embryonic development. The review involves the collection and analysis of information about the characteristics of EBs and the properties of stem cells that give rise to them. The results show that EBs derived from pluripotent stem cells are a promising model that closely replicates processes occurring in human embryos after implantation. The review also provides a comparative analysis of the advantages and limitations of models based on induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), with particular attention given to summarizing the results of limited studies on RNA sequencing in individual cells from human and mouse EBs. In conclusion, we would like to emphasize that embryoid bodies are an effective model system for studying early human embryogenesis. This opens up new possibilities for reproductive genetics and medicine.
期刊介绍：
The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species.
The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.
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