Yunjeong Park, Heechul Jeong, Jung-Ho Shin, Geum Joon Cho, Yong Jin Kim
{"title":"卵巢过度刺激综合征与韩国不良产科和新生儿结局之间的关系：一项全国性健康保险数据库研究。","authors":"Yunjeong Park, Heechul Jeong, Jung-Ho Shin, Geum Joon Cho, Yong Jin Kim","doi":"10.1007/s10815-025-03542-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the association of ovarian hyperstimulation syndrome (OHSS) and adverse maternal and neonatal outcomes.</p><p><strong>Methods: </strong>This retrospective study used combined Korea National Health Insurance (KNHI) claims and National Health Screening Program for Infants and Children data. Women who gave birth through in vitro fertilization using fresh embryo transfer during 2017-2022 were enrolled. Z-scores were calculated. Student's t-test, analysis of variance, Pearson's chi-squared (χ<sup>2</sup>) test, and multivariate logistic regression analyses were performed.</p><p><strong>Results: </strong>The non-OHSS group included 27,337 women, while the OHSS group included 1,570 women (mild to moderate, 1,308; severe, 262). The OHSS group was significantly younger (34.86 ± 3.54 vs. 36.21 ± 3.58 years, p < 0.0001) and had significantly higher rates of primiparity, cesarean section, and polycystic ovary syndrome (88.98% vs. 82.89%, p < 0.0001; 75.8% vs. 65.75%, p < 0.0001; and 29.24% vs. 14.37%, p < 0.0001, respectively). OHSS was associated with a decreased incidence of low birth weight and with an increased incidence of macrosomia (adjusted odds ratio [95% confidence interval], 0.53 [0.38-0.72], p < 0.0001; and 1.83 [1.42-2.35], p < 0.0001). OHSS was associated with an increased incidence of transient tachypnea of the newborn (TTN) and respiratory distress syndrome (RDS) (1.32 [1.02-1.71], p = 0.03; and 1.57 [1.30-1.91], p < 0.0001).</p><p><strong>Conclusion: </strong>OHSS is associated with a decreased incidence of low birth weight and an increased incidence of macrosomia, TTN, and RDS.</p>","PeriodicalId":15246,"journal":{"name":"Journal of Assisted Reproduction and Genetics","volume":" ","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between ovarian hyperstimulation syndrome and adverse obstetric and neonatal outcomes in Korea: a nationwide health insurance database study.\",\"authors\":\"Yunjeong Park, Heechul Jeong, Jung-Ho Shin, Geum Joon Cho, Yong Jin Kim\",\"doi\":\"10.1007/s10815-025-03542-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To investigate the association of ovarian hyperstimulation syndrome (OHSS) and adverse maternal and neonatal outcomes.</p><p><strong>Methods: </strong>This retrospective study used combined Korea National Health Insurance (KNHI) claims and National Health Screening Program for Infants and Children data. Women who gave birth through in vitro fertilization using fresh embryo transfer during 2017-2022 were enrolled. Z-scores were calculated. Student's t-test, analysis of variance, Pearson's chi-squared (χ<sup>2</sup>) test, and multivariate logistic regression analyses were performed.</p><p><strong>Results: </strong>The non-OHSS group included 27,337 women, while the OHSS group included 1,570 women (mild to moderate, 1,308; severe, 262). The OHSS group was significantly younger (34.86 ± 3.54 vs. 36.21 ± 3.58 years, p < 0.0001) and had significantly higher rates of primiparity, cesarean section, and polycystic ovary syndrome (88.98% vs. 82.89%, p < 0.0001; 75.8% vs. 65.75%, p < 0.0001; and 29.24% vs. 14.37%, p < 0.0001, respectively). OHSS was associated with a decreased incidence of low birth weight and with an increased incidence of macrosomia (adjusted odds ratio [95% confidence interval], 0.53 [0.38-0.72], p < 0.0001; and 1.83 [1.42-2.35], p < 0.0001). OHSS was associated with an increased incidence of transient tachypnea of the newborn (TTN) and respiratory distress syndrome (RDS) (1.32 [1.02-1.71], p = 0.03; and 1.57 [1.30-1.91], p < 0.0001).</p><p><strong>Conclusion: </strong>OHSS is associated with a decreased incidence of low birth weight and an increased incidence of macrosomia, TTN, and RDS.</p>\",\"PeriodicalId\":15246,\"journal\":{\"name\":\"Journal of Assisted Reproduction and Genetics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Assisted Reproduction and Genetics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10815-025-03542-1\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Assisted Reproduction and Genetics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10815-025-03542-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Association between ovarian hyperstimulation syndrome and adverse obstetric and neonatal outcomes in Korea: a nationwide health insurance database study.
Purpose: To investigate the association of ovarian hyperstimulation syndrome (OHSS) and adverse maternal and neonatal outcomes.
Methods: This retrospective study used combined Korea National Health Insurance (KNHI) claims and National Health Screening Program for Infants and Children data. Women who gave birth through in vitro fertilization using fresh embryo transfer during 2017-2022 were enrolled. Z-scores were calculated. Student's t-test, analysis of variance, Pearson's chi-squared (χ2) test, and multivariate logistic regression analyses were performed.
Results: The non-OHSS group included 27,337 women, while the OHSS group included 1,570 women (mild to moderate, 1,308; severe, 262). The OHSS group was significantly younger (34.86 ± 3.54 vs. 36.21 ± 3.58 years, p < 0.0001) and had significantly higher rates of primiparity, cesarean section, and polycystic ovary syndrome (88.98% vs. 82.89%, p < 0.0001; 75.8% vs. 65.75%, p < 0.0001; and 29.24% vs. 14.37%, p < 0.0001, respectively). OHSS was associated with a decreased incidence of low birth weight and with an increased incidence of macrosomia (adjusted odds ratio [95% confidence interval], 0.53 [0.38-0.72], p < 0.0001; and 1.83 [1.42-2.35], p < 0.0001). OHSS was associated with an increased incidence of transient tachypnea of the newborn (TTN) and respiratory distress syndrome (RDS) (1.32 [1.02-1.71], p = 0.03; and 1.57 [1.30-1.91], p < 0.0001).
Conclusion: OHSS is associated with a decreased incidence of low birth weight and an increased incidence of macrosomia, TTN, and RDS.
期刊介绍：
The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species.
The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.
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