Mahvash Sadeghi, Sajad Dehnavi, Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Alexandra E Butler, Tannaz Jamialahmadi, Amirhossein Sahebkar
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引用次数: 0
摘要
他汀类药物可抑制3-羟基-3-甲基戊二酰辅酶A (HMG CoA)还原酶;它们通常用于降低胆固醇水平,以达到保护心脏的目的。进一步的研究表明,他汀类药物具有不依赖于降低胆固醇的特性,并具有多种治疗特性,包括抗氧化、抗炎、抗纤维化、神经保护和其他有益作用。包括选择素、整合素、钙粘蛋白、CD44和免疫球蛋白超家族(IgSF)成员在内的粘附分子是这些生物学功能的重要介质。目前的综述讨论了在体外和体内生理和病理模型中进行的研究,重点关注粘附分子,如淋巴细胞功能相关抗原-1 (LFA-1),巨噬细胞-1抗原(Mac-1), p -选择素,e-选择素,非常晚活化抗原-4 (vla4)和连接素,这些是不同类型的他汀类药物的治疗靶点,并强调了他汀类药物对心血管疾病以外疾病的潜在治疗效用。
Statins and adhesion molecules: a review of a novel pleiotropic property of statins.
Statins were introduced as lipid-lowering agents that inhibit 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG CoA) reductase; they are commonly administered to reduce cholesterol levels for cardioprotective purposes. Further studies suggested that statins have cholesterol-reducing-independent properties and exert pleiotropic therapeutic properties, including antioxidant, anti-inflammatory, anti-fibrotic, neuroprotective, and other beneficial effects. Adhesion molecules, including selectins, integrins, cadherins, CD44, and the immunoglobulin superfamily (IgSF) members, are essential mediators for those biological functions. The current review discusses studies performed in in vitro and in vivo in physiological and pathological models focusing on adhesion molecules such as Lymphocyte function-associated antigen-1 (LFA-1), macrophage-1 antigen (Mac-1), P-selectin, E-selectin, very late activation antigens-4 (VLA-4), and nectins that are therapeutically targeted by different types of statins and that highlight the potential therapeutic utility of statins for diseases other than cardiovascular disease.
期刊介绍:
IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.