CAD中的CircRNA网络：多细胞机制和临床潜力。

IF 2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2025-06-12 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S524189

Huan Cheng, Xinyu Wu, Jingru Li, Luqiao Wang

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引用次数: 0

摘要

冠状动脉疾病（CAD）是一种以冠状动脉闭塞引起心肌缺血、缺氧为特征的全球性心血管疾病。环状RNA （CircRNAs）是一类特殊的内源性非编码RNA，可影响CAD的发生和发展。同时，一些circrna在CAD患者中表现出稳定的持续性，这归因于它们异常的外切酶抗性，从而具有演变成CAD诊断和预后的生物标志物的能力。本文基于circRNAs独特的生物学特性和功能，试图阐明其在CAD患者或CAD疾病模型复杂的病理生理过程中的关键作用，并进一步讨论其在CAD临床应用中的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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CircRNA Networks in CAD: Multi-Cellular Mechanisms and Clinical Potential.

Coronary artery disease (CAD), is a global cardiovascular disease that is characterized by myocardial ischemia and hypoxia caused by coronary artery occlusion. Circular RNAs (CircRNAs) is a particular kind of endogenous non-coding RNA, which can affect the occurrence and development of CAD. Concurrently, several circRNAs display stable persistence in CAD patients, attributable to their exceptional exonuclease resistance, thereby harboring the capacity to evolve into a biomarker for CAD diagnosis and prognosis. This article endeavors to clarify the pivotal role of circRNAs in the intricate pathophysiological processes underlying CAD patients or CAD disease models based on their unique biological characteristics and functionalities, and further discuss their prospects in clinical applications of CAD.

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.