经睑电刺激恢复NAION患者视觉功能1例。

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
Salvatore Martella, Paolo Ferri, Leonardo Colombo, Giulia Torregrossa, Emanuele Mocciardini, Jacopo Baldesi, Chiara Quisisana, Luca Rossetti
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引用次数: 0

摘要

非动脉性前缺血性视神经病变(NAION)是中老年人群视力丧失的主要原因,目前尚无有效的治疗方法。电刺激(ES)在视神经病变中显示出保存和恢复神经功能的潜力。本研究探讨经睑ES对改善NAION所致长期视力损害患者视力功能的疗效。方法一名62岁男性双眼连续性NAION患者接受60天、每天20分钟的经睑ES治疗。在基线和治疗30天和60天后评估视力功能,包括最佳矫正视力(BCVA)、对比敏感度、视野(VF)分析和显微视野。结果治疗60天后,BCVA有显著改善,右眼ETDRS字母增加11个,左眼ETDRS字母增加18个。两只眼睛的对比敏感度也有所提高。视野参数包括平均偏差、模式标准差和视野指数均有显著增强。显微检查显示黄斑敏感性增加,固定稳定性提高。患者还报告了主观改善。未发现不良事件。ones已被证明通过调节神经元兴奋性、激活神经保护信号通路和潜在地支持神经再生来增强视网膜功能。在我们的病例中,经睑ES与长期nion相关视力损害患者的视觉功能有意义的改善相关。尽管需要进一步的研究来证实这些结果并优化治疗方案,但这些结果表明ES是治疗NAION的一种很有前景的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Restoring visual function in NAION by means of transpalpebral electrical stimulation: A case report.

IntroductionNon-arteritic anterior ischemic optic neuropathy (NAION) is a major cause of vision loss in middle-aged and elderly populations, with no effective treatment currently available. Electrical stimulation (ES) has shown potential in preserving and restoring neural function in optic neuropathies. This study investigates the efficacy of transpalpebral ES in improving visual function in a patient with long-term visual impairment due to NAION.MethodsA 62-year-old male patient with sequential NAION in both eyes underwent a 60-day transpalpebral ES for 20 min daily. Visual function was assessed at baseline and after 30 and 60 days of treatment, including best-corrected visual acuity (BCVA), contrast sensitivity, visual field (VF) analysis, and microperimetry.ResultsSignificant improvements in BCVA were detected, with an overall increase of 11 ETDRS letters in the right eye and 18 in the left eye after 60 days of treatment. Contrast sensitivity also improved in both eyes. Visual field parameters, including mean deviation, pattern standard deviation and visual field index, showed notable enhancements. Microperimetry revealed increased macular sensitivity and improved fixation stability. The patient also reported subjective improvements. No adverse events were noted.DiscussionES has been shown to enhance retinal function by modulating neuronal excitability, activating neuroprotective signaling pathways, and potentially supporting neural regeneration. In our case, transpalpebral ES was associated with meaningful improvements in visual function in a patient with long-term NAION-related visual impairment. These results suggest ES as a promising approach for NAION, though further research is needed to confirm these results and optimize treatment protocols.

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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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