{"title":"反复强中央凹红光治疗儿童近视前期的效果:随机对照试验的系统评价和meta分析。","authors":"Matheus Henrique Monteiro Leber, Tanize Louize Milbradt, Alexandre Yamada Fujimura, Yasmin Picanco Silva, Dillan Cunha Amaral, Henrique Monteiro Leber, Rubens Belfort","doi":"10.1080/02713683.2025.2516007","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Myopia is a significant public health concern with increased risk of ocular complications. Intense Foveal Red Light (IFRL) therapy has been explored in myopia control, but its efficacy at the pre-myopic stage remains underexplored. The use of this therapy in a population without a myopia diagnosis may offer a new window for the prophylactic application of IFRL therapy. The purpose of this meta-analysis is to determine the effectiveness of IFRL therapy in children with pre-myopia.</p><p><strong>Methods: </strong>PubMed, Embase, and the Cochrane Library were systematically searched for studies investigating the effects of IFRL therapy on myopia incidence, changes in axial length (AL), choroidal thickness (CT), and cycloplegic spherical equivalent refraction (SER). Two independent reviewers screened studies, extracted data, and assessed the risk of bias. Meta-analyses were conducted using random-effects models to estimate the pooled effect sizes.</p><p><strong>Results: </strong>Of 365 studies identified, 4 met the criteria, totaling 619 participants (mean age 8.48 years, 51.8% female). At 6 months, IFRL significantly reduced myopia incidence (Risk Difference [RD] - 0.1; 95% CI -0.15 to -0.05; <i>p</i> < 0.01), with benefits persisting at 12 months (RD -0.17; 95% CI -0.26 to 0.09; <i>p</i> < 0.01). IFRL also reduced AL at 6 months (Mean Difference [MD] - 0.12 mm; 95% CI -0.16 to -0.09; <i>p</i> < 0.01) and 12 months (MD -0.18 mm; 95% CI -0.23 to -0.14; <i>p</i> < 0.01), increased CT (MD 22.34 µm; 95% CI 5.45-39.24; <i>p</i> < 0.01), and improved SER at 6 (MD 0.27 D; 95% CI 0.23 to 0.32; <i>p</i> < 0.01) and 12 months (MD 0.36 D; 95% CI 0.27-0.46; <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>IFRL effectively reduced myopia incidence, AL, and improved SER and CT. These findings support further research on its long-term efficacy and safety, particularly regarding potential adverse effects and durability of outcomes. Overall, IFRL may offer a preventive strategy for pre-myopic children.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-9"},"PeriodicalIF":2.0000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Repeated Intense Foveal Red-Light Therapy in Children with Pre-Myopia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.\",\"authors\":\"Matheus Henrique Monteiro Leber, Tanize Louize Milbradt, Alexandre Yamada Fujimura, Yasmin Picanco Silva, Dillan Cunha Amaral, Henrique Monteiro Leber, Rubens Belfort\",\"doi\":\"10.1080/02713683.2025.2516007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Myopia is a significant public health concern with increased risk of ocular complications. Intense Foveal Red Light (IFRL) therapy has been explored in myopia control, but its efficacy at the pre-myopic stage remains underexplored. The use of this therapy in a population without a myopia diagnosis may offer a new window for the prophylactic application of IFRL therapy. The purpose of this meta-analysis is to determine the effectiveness of IFRL therapy in children with pre-myopia.</p><p><strong>Methods: </strong>PubMed, Embase, and the Cochrane Library were systematically searched for studies investigating the effects of IFRL therapy on myopia incidence, changes in axial length (AL), choroidal thickness (CT), and cycloplegic spherical equivalent refraction (SER). Two independent reviewers screened studies, extracted data, and assessed the risk of bias. Meta-analyses were conducted using random-effects models to estimate the pooled effect sizes.</p><p><strong>Results: </strong>Of 365 studies identified, 4 met the criteria, totaling 619 participants (mean age 8.48 years, 51.8% female). At 6 months, IFRL significantly reduced myopia incidence (Risk Difference [RD] - 0.1; 95% CI -0.15 to -0.05; <i>p</i> < 0.01), with benefits persisting at 12 months (RD -0.17; 95% CI -0.26 to 0.09; <i>p</i> < 0.01). IFRL also reduced AL at 6 months (Mean Difference [MD] - 0.12 mm; 95% CI -0.16 to -0.09; <i>p</i> < 0.01) and 12 months (MD -0.18 mm; 95% CI -0.23 to -0.14; <i>p</i> < 0.01), increased CT (MD 22.34 µm; 95% CI 5.45-39.24; <i>p</i> < 0.01), and improved SER at 6 (MD 0.27 D; 95% CI 0.23 to 0.32; <i>p</i> < 0.01) and 12 months (MD 0.36 D; 95% CI 0.27-0.46; <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>IFRL effectively reduced myopia incidence, AL, and improved SER and CT. These findings support further research on its long-term efficacy and safety, particularly regarding potential adverse effects and durability of outcomes. Overall, IFRL may offer a preventive strategy for pre-myopic children.</p>\",\"PeriodicalId\":10782,\"journal\":{\"name\":\"Current Eye Research\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Eye Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02713683.2025.2516007\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Eye Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02713683.2025.2516007","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:近视是一个重要的公共卫生问题,眼部并发症的风险增加。强中央凹红光(IFRL)疗法已被用于控制近视,但其在近视前期的疗效尚不清楚。在没有近视诊断的人群中使用这种疗法可能为IFRL治疗的预防性应用提供一个新的窗口。本荟萃分析的目的是确定IFRL治疗近视前期儿童的有效性。方法:系统检索PubMed、Embase和Cochrane图书馆,研究IFRL治疗对近视发生率、眼轴长度(AL)、脉络膜厚度(CT)和睫状体麻痹球等效屈光度(SER)的影响。两名独立审稿人筛选研究、提取数据并评估偏倚风险。使用随机效应模型进行meta分析以估计合并效应大小。结果:在365项研究中,4项符合标准,共619名参与者(平均年龄8.48岁,女性51.8%)。6个月时,IFRL显著降低近视发生率(风险差[RD] - 0.1;95% CI为-0.15 ~ -0.05;p p p p p p p结论:IFRL可有效降低近视发生率和AL,改善SER和CT。这些发现支持对其长期有效性和安全性的进一步研究,特别是关于潜在的不良反应和结果的持久性。总之,IFRL可能为近视前期儿童提供一种预防策略。
Effect of Repeated Intense Foveal Red-Light Therapy in Children with Pre-Myopia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Purpose: Myopia is a significant public health concern with increased risk of ocular complications. Intense Foveal Red Light (IFRL) therapy has been explored in myopia control, but its efficacy at the pre-myopic stage remains underexplored. The use of this therapy in a population without a myopia diagnosis may offer a new window for the prophylactic application of IFRL therapy. The purpose of this meta-analysis is to determine the effectiveness of IFRL therapy in children with pre-myopia.
Methods: PubMed, Embase, and the Cochrane Library were systematically searched for studies investigating the effects of IFRL therapy on myopia incidence, changes in axial length (AL), choroidal thickness (CT), and cycloplegic spherical equivalent refraction (SER). Two independent reviewers screened studies, extracted data, and assessed the risk of bias. Meta-analyses were conducted using random-effects models to estimate the pooled effect sizes.
Results: Of 365 studies identified, 4 met the criteria, totaling 619 participants (mean age 8.48 years, 51.8% female). At 6 months, IFRL significantly reduced myopia incidence (Risk Difference [RD] - 0.1; 95% CI -0.15 to -0.05; p < 0.01), with benefits persisting at 12 months (RD -0.17; 95% CI -0.26 to 0.09; p < 0.01). IFRL also reduced AL at 6 months (Mean Difference [MD] - 0.12 mm; 95% CI -0.16 to -0.09; p < 0.01) and 12 months (MD -0.18 mm; 95% CI -0.23 to -0.14; p < 0.01), increased CT (MD 22.34 µm; 95% CI 5.45-39.24; p < 0.01), and improved SER at 6 (MD 0.27 D; 95% CI 0.23 to 0.32; p < 0.01) and 12 months (MD 0.36 D; 95% CI 0.27-0.46; p < 0.01).
Conclusion: IFRL effectively reduced myopia incidence, AL, and improved SER and CT. These findings support further research on its long-term efficacy and safety, particularly regarding potential adverse effects and durability of outcomes. Overall, IFRL may offer a preventive strategy for pre-myopic children.
期刊介绍:
The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.