内镜胃重塑（EGR）对胃食管反流病（GERD）的影响

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Translational Gastroenterology Pub Date : 2025-06-17 DOI:10.14309/ctg.0000000000000867

Pichamol Jirapinyo, David Leung, Walter W Chan, Christopher C Thompson

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引用次数: 0

摘要

简介：袖式胃切除术与胃食管反流病（GERD）发病率增加相关。相比之下，内镜下胃重塑（EGR）对胃反流症状的影响尚不清楚。方法：这项前瞻性研究纳入了接受EGR的患者，并在基线和术后12个月完成了经验证的gerd相关患者报告的结果问卷。结果：纳入50例患者。在egr后12个月，GERD-Q和反流症状指数评分均显著改善。质子泵抑制剂（PPI）的使用从基线时的38%下降到12个月时的20% （p=0.047）。基线时裂孔疝的存在与更大的症状改善相关。讨论：EGR改善了典型和非典型反流症状，减少了对PPI的依赖。对于伴有肥胖和反流的患者，它可能是一种较好的治疗选择。

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The Impact of Endoscopic Gastric Remodeling on Gastroesophageal Reflux Disease.

Introduction: Sleeve gastrectomy is associated with an increased incidence of gastroesophageal reflux disease (GERD). By contrast, the impact of endoscopic gastric remodeling (EGR) on GERD symptoms remains unclear.

Methods: This prospective study included patients who underwent EGR and completed validated GERD-related patient-reported outcome questionnaires at baseline and 12 months postprocedure.

Results: Fifty patients were included. At 12 months post-EGR, both GERD questionnaire and Reflux Symptom Index scores significantly improved. Proton-pump inhibitor use decreased from 38% at baseline to 20% at 12 months ( P = 0.047). The presence of a hiatal hernia at baseline was associated with greater symptom improvement.

Discussion: EGR improves both typical and atypical GERD symptoms and reduces proton-pump inhibitor dependence. It may represent a preferable treatment option for patients with obesity and concomitant GERD.

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.