小鼠皮肤中apelin受体表达和定位的性别差异。

IF 2.2 4区 生物学 Q3 CELL BIOLOGY
Milirani Das, Rahul Kumar, Vikash Kumar, Guruswami Gurusubramanian, Vikas Kumar Roy
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引用次数: 0

摘要

雄性和雌性老鼠的皮肤结构不同。瘦素、脂联素、抵抗素和网膜素是脂肪因子,在皮肤中表达。Apelin是一种脂肪因子,可与其受体(APJ)结合,在不同组织中发挥多种生物学功能。而APJ和apelin在小鼠皮肤中未见表达。由于雌雄不同,因此,我们假设apelin和APJ的表达也可能存在性别差异。结果表明,apelin和APJ在男女皮肤的表皮层、毛囊和皮脂腺中均有表达。这一结果表明,蜕皮素介导的信号传导在男性和女性皮肤中可能是不同的。女性皮肤的毛囊和皮脂腺中也有大量的尖蛋白,这进一步说明了尖蛋白在头发生长和皮脂腺功能中的作用。皮肤中apelin介导的信号可能与性别有关。女性皮肤er表达升高与APJ和apelin表达升高一致,男性皮肤APJ和apelin表达降低与雄激素受体表达降低一致。因此,性激素信号可能是皮肤中apelin和APJ表达的性别差异的原因。此外,apelin信号对于男性和女性皮肤生理过程都很重要,然而,与男性皮肤相比,apelin信号在女性皮肤中可能更明显。性别基尖蛋白信号在关系增殖中的确切作用有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gender differences in expression and localization of the apelin receptor in mice skin.

The male and female mouse skin differs in their structure. Leptin, adiponectin, resistin and omentin are adipokines, which expresses in the skin. Apelin is an adipokines, which binds to a its receptor (APJ) and elicits various biological functions in the different tissues. However, the expression of apelin and APJ has not been shown in the mice skin. Since the male female differs, thus, it is hypothesized that apelin and APJ expression might also show gender-wise differences. Our results showed that apelin and APJ are expressed in the epidermal layer, hair follicle and sebaceous glands of male and female skin. This result suggests that apelin-mediated signalling could be different in the male and female skin. Hair follicle and sebaceous gland in the female skin also showed an increased abundance of apelin, which further suggests the role of apelin, in hair growth and sebaceous gland functions. Apelin-mediated signaling in the skin might be gender-dependent. Elevated expression of ERs in female skin coincides with increased apelin and APJ and decreased apelin and APJ expression in male skin coincides with the decreased androgen receptor. Thus, it may be suggested that sex hormonal signaling could be reason for gender wise difference in apelin and APJ expression in skin. Furthermore, apelin signaling would be important for both male and female skin physiological processes, however, apelin signaling could be pronounced in the female skin compared to the male skin. The exact role of gender base apelin signaling needs further investigation in relation proliferation.

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来源期刊
Journal of Molecular Histology
Journal of Molecular Histology 生物-细胞生物学
CiteScore
5.90
自引率
0.00%
发文量
68
审稿时长
1 months
期刊介绍: The Journal of Molecular Histology publishes results of original research on the localization and expression of molecules in animal cells, tissues and organs. Coverage includes studies describing novel cellular or ultrastructural distributions of molecules which provide insight into biochemical or physiological function, development, histologic structure and disease processes. Major research themes of particular interest include: - Cell-Cell and Cell-Matrix Interactions; - Connective Tissues; - Development and Disease; - Neuroscience. Please note that the Journal of Molecular Histology does not consider manuscripts dealing with the application of immunological or other probes on non-standard laboratory animal models unless the results are clearly of significant and general biological importance. The Journal of Molecular Histology publishes full-length original research papers, review articles, short communications and letters to the editors. All manuscripts are typically reviewed by two independent referees. The Journal of Molecular Histology is a continuation of The Histochemical Journal.
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