Rh（III）催化的恶二唑酮与cf3 -咪酰亚砜酰化物的环化：获得三氟甲基取代的融合二氢异喹啉。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-22 DOI:10.1039/d5ob00732a

Sihao Ling , Qihua Chen , Zhengkai Chen

引用次数: 0

摘要

研究了一种铑（III）催化氧化还原-中性C(sp2)-H键活化和环化恶二唑酮类化合物和cf3取代的咪甲酰亚砜酰化物（TFISYs）。级联C(sp2)-H键氨基甲基化和随后的分子内亲核加成序列可能参与了转化，提供了直接获得各种三氟甲基和含氨基的融合二氢异喹啉的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rh(iii)-catalyzed annulation of oxadiazolones with CF3-imidoyl sulfoxonium ylides: access to trifluoromethyl-substituted fused-dihydroisoquinolines†

查看原文本刊更多论文

Rh(iii)-catalyzed annulation of oxadiazolones with CF3-imidoyl sulfoxonium ylides: access to trifluoromethyl-substituted fused-dihydroisoquinolines†

A rhodium(iii)-catalyzed redox-neutral C(sp²)–H bond activation and annulation of oxadiazolones and CF₃-substituted imidoyl sulfoxonium ylides (TFISYs) has been developed. A cascade C(sp²)–H bond imidoylmethylation and subsequent intramolecular nucleophilic addition sequence might be involved in the transformation, providing direct access to diverse trifluoromethyl and amino-containing fused-dihydroisoquinolines.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.