基于聚乙二醇的抗菌肽模拟物（Pegtides）。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2025-06-18 DOI:10.1002/cbic.202500258

Conor Shine, John R F B Connolly, Robert D Murphy, Hazel Lafferty, Abdalmalek Alfnikh, Ned P Buijs, Hawraa Shahrour, Nathaniel I Martin, Eoghan O'Neill, George Amarandei, Jimmy Muldoon, Marc Maresca, Deirdre Fitzgerald-Hughes, Marc Devocelle

{"title":"基于聚乙二醇的抗菌肽模拟物（Pegtides）。","authors":"Conor Shine, John R F B Connolly, Robert D Murphy, Hazel Lafferty, Abdalmalek Alfnikh, Ned P Buijs, Hawraa Shahrour, Nathaniel I Martin, Eoghan O'Neill, George Amarandei, Jimmy Muldoon, Marc Maresca, Deirdre Fitzgerald-Hughes, Marc Devocelle","doi":"10.1002/cbic.202500258","DOIUrl":null,"url":null,"abstract":"Cationic amphipathic poly(ethylene glycol)-based polymers are generated with synthetic efficiencies allowing their evaluation as antimicrobial peptide (AMP) mimetics. Accordingly, statistical copolymers with cationic units consistently functionalized with guanyl groups, but different side-chain lengths, and hydrophobic units displaying long aliphatic, branched, and/or aromatic side chains are produced and tested for their antimicrobial and hemolytic properties. The results obtained indicate that candidates with activities and selectivity commensurate to some AMPs can be obtained and that further development of this novel type of antimicrobial peptidomimetics, pegtides, is warranted for clinical and/or biotechnological applications.","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e2500258"},"PeriodicalIF":2.6000,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Poly(ethylene Glycol)-Based Peptidomimetics (Pegtides) of Antimicrobial Peptides.\",\"authors\":\"Conor Shine, John R F B Connolly, Robert D Murphy, Hazel Lafferty, Abdalmalek Alfnikh, Ned P Buijs, Hawraa Shahrour, Nathaniel I Martin, Eoghan O'Neill, George Amarandei, Jimmy Muldoon, Marc Maresca, Deirdre Fitzgerald-Hughes, Marc Devocelle\",\"doi\":\"10.1002/cbic.202500258\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cationic amphipathic poly(ethylene glycol)-based polymers are generated with synthetic efficiencies allowing their evaluation as antimicrobial peptide (AMP) mimetics. Accordingly, statistical copolymers with cationic units consistently functionalized with guanyl groups, but different side-chain lengths, and hydrophobic units displaying long aliphatic, branched, and/or aromatic side chains are produced and tested for their antimicrobial and hemolytic properties. The results obtained indicate that candidates with activities and selectivity commensurate to some AMPs can be obtained and that further development of this novel type of antimicrobial peptidomimetics, pegtides, is warranted for clinical and/or biotechnological applications.\",\"PeriodicalId\":140,\"journal\":{\"name\":\"ChemBioChem\",\"volume\":\" \",\"pages\":\"e2500258\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-06-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemBioChem\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1002/cbic.202500258\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/cbic.202500258","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

阳离子两亲性聚乙二醇（PEG）基聚合物的合成效率使其能够作为抗菌肽（AMP）模拟物进行评估。因此，生产了具有阳离子单元的统计共聚物，这些共聚物具有恒定的官能团，但侧链长度不同，以及具有长脂肪、支链和/或芳香侧链的疏水单元，并对其抗菌和溶血性能进行了测试。所获得的结果表明，可以获得具有与某些amp相当的活性和选择性的候选物，并且可以进一步开发这种新型抗菌肽模拟物（pegtides），以用于临床和/或生物技术应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Poly(ethylene Glycol)-Based Peptidomimetics (Pegtides) of Antimicrobial Peptides.

Cationic amphipathic poly(ethylene glycol)-based polymers are generated with synthetic efficiencies allowing their evaluation as antimicrobial peptide (AMP) mimetics. Accordingly, statistical copolymers with cationic units consistently functionalized with guanyl groups, but different side-chain lengths, and hydrophobic units displaying long aliphatic, branched, and/or aromatic side chains are produced and tested for their antimicrobial and hemolytic properties. The results obtained indicate that candidates with activities and selectivity commensurate to some AMPs can be obtained and that further development of this novel type of antimicrobial peptidomimetics, pegtides, is warranted for clinical and/or biotechnological applications.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).