氘化1,3二氢- 2H -吲哚-2- 1衍生物用于治疗抑郁或焦虑。

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL

ACS Medicinal Chemistry Letters Pub Date : 2025-05-28 eCollection Date: 2025-06-12 DOI:10.1021/acsmedchemlett.5c00284

Qi-Long Hu, Steven H Liang

引用次数: 0

摘要

本专利申请公开了一系列靶向抗利空激素1b受体（V1b）或V1a和V1b受体的1,3 -二氢- 2h -吲哚-2- 1衍生物，如式1所示。这些抗利空激素受体拮抗剂具有显著的治疗潜力，特别是在治疗抑郁症或焦虑症方面，并且有望减少给药频率，使患者受益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Deuterated 1,3 Dihydro‑2H‑indole-2-one Derivatives for Treatment of Depression or Anxiety.

This patent application discloses a series of l,3-dihydro-2H-indol-2-one derivatives targeting the vasopressin 1b receptor (V_1b) or both the V_1a and V_1b receptors, as represented by Formula I. These vasopressin receptor antagonists exhibit significant therapeutic potential, particularly for the treatment of depression or anxiety, and hold promises for benefiting patients with reduced dosing frequency.

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.