在Framingham后代队列中，支持高质量碳水化合物的低碳水化合物饮食模式与炎症和氧化应激生物标志物的有益长期变化有关

IF 3.2 Q2 NUTRITION & DIETETICS

Current Developments in Nutrition Pub Date : 2025-05-28 DOI:10.1016/j.cdnut.2025.107479

Ghaida F Aloraini , Nicola M McKeown , Gail T Rogers , Sai Krupa Das , Alice H Lichtenstein , Paul F Jacques

{"title":"在Framingham后代队列中，支持高质量碳水化合物的低碳水化合物饮食模式与炎症和氧化应激生物标志物的有益长期变化有关","authors":"Ghaida F Aloraini , Nicola M McKeown , Gail T Rogers , Sai Krupa Das , Alice H Lichtenstein , Paul F Jacques","doi":"10.1016/j.cdnut.2025.107479","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Low-carbohydrate diet (LCD) patterns have been studied as a potential strategy to reduce chronic inflammation. Evidence remains equivocal, likely because of differences in the quality of carbohydrate sources among LCD patterns.</div></div><div><h3>Objectives</h3><div>To prospectively examine the associations between LCD patterns varying in carbohydrate quality, and changes of inflammation and oxidative stress biomarkers.</div></div><div><h3>Methods</h3><div>Among Framingham Offspring Study participants (<em>n</em> = 2225; median 6.7-y follow-up, mean baseline age: 60.1 y), we used food frequency questionnaires to create 2 LCD scores (LCDS) accounting for quality of carbohydrates sources. These reflected higher intake of total fat and protein, and lower intake of either low-quality carbohydrates [high-quality LCDS (HQ-LCDS)] or high-quality carbohydrates [low-quality LCDS (LQ-LCDS)]. We calculated an inflammation and oxidative stress score by summing the standardized values of 9 inflammatory and oxidative stress biomarkers. Least-square mean change in the inflammation and oxidative stress score across quintile categories of LCDS was estimated using multivariable linear regression models, adjusted for potential confounders.</div></div><div><h3>Results</h3><div>HQ-LCDS was inversely associated with change in the inflammation and oxidative stress score (mean ± SE in Q1: 0.24 ± 0.16, Q5: −0.27 ± 0.16; <em>P</em><sub>trend</sub> = 0.004), indicating that inflammation and oxidative stress increased in those in the lowest HQ-LCDS category and decreased in those in the highest category. HQ-LCDS was also inversely associated with changes in intercellular adhesion molecule-1 (<em>P</em><sub>trend</sub> = 0.003) and lipoprotein phospholipase A2 activity (<em>P</em><sub>trend</sub> = 0.003). No significant associations were observed for LQ-LCDS.</div></div><div><h3>Conclusions</h3><div>LCD patterns that preserved high-quality carbohydrates while replacing low-quality carbohydrates sources, such as refined grains and added sugars, with fat and protein were inversely associated with inflammation and oxidative stress score, potentially lowering chronic disease risk.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 7","pages":"Article 107479"},"PeriodicalIF":3.2000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Low-Carbohydrate Diet Patterns That Favor High-Quality Carbohydrates Are Associated with Beneficial Long-Term Changes in Biomarkers of Inflammation and Oxidative Stress in the Framingham Offspring Cohort\",\"authors\":\"Ghaida F Aloraini , Nicola M McKeown , Gail T Rogers , Sai Krupa Das , Alice H Lichtenstein , Paul F Jacques\",\"doi\":\"10.1016/j.cdnut.2025.107479\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Low-carbohydrate diet (LCD) patterns have been studied as a potential strategy to reduce chronic inflammation. Evidence remains equivocal, likely because of differences in the quality of carbohydrate sources among LCD patterns.</div></div><div><h3>Objectives</h3><div>To prospectively examine the associations between LCD patterns varying in carbohydrate quality, and changes of inflammation and oxidative stress biomarkers.</div></div><div><h3>Methods</h3><div>Among Framingham Offspring Study participants (<em>n</em> = 2225; median 6.7-y follow-up, mean baseline age: 60.1 y), we used food frequency questionnaires to create 2 LCD scores (LCDS) accounting for quality of carbohydrates sources. These reflected higher intake of total fat and protein, and lower intake of either low-quality carbohydrates [high-quality LCDS (HQ-LCDS)] or high-quality carbohydrates [low-quality LCDS (LQ-LCDS)]. We calculated an inflammation and oxidative stress score by summing the standardized values of 9 inflammatory and oxidative stress biomarkers. Least-square mean change in the inflammation and oxidative stress score across quintile categories of LCDS was estimated using multivariable linear regression models, adjusted for potential confounders.</div></div><div><h3>Results</h3><div>HQ-LCDS was inversely associated with change in the inflammation and oxidative stress score (mean ± SE in Q1: 0.24 ± 0.16, Q5: −0.27 ± 0.16; <em>P</em><sub>trend</sub> = 0.004), indicating that inflammation and oxidative stress increased in those in the lowest HQ-LCDS category and decreased in those in the highest category. HQ-LCDS was also inversely associated with changes in intercellular adhesion molecule-1 (<em>P</em><sub>trend</sub> = 0.003) and lipoprotein phospholipase A2 activity (<em>P</em><sub>trend</sub> = 0.003). No significant associations were observed for LQ-LCDS.</div></div><div><h3>Conclusions</h3><div>LCD patterns that preserved high-quality carbohydrates while replacing low-quality carbohydrates sources, such as refined grains and added sugars, with fat and protein were inversely associated with inflammation and oxidative stress score, potentially lowering chronic disease risk.</div></div>\",\"PeriodicalId\":10756,\"journal\":{\"name\":\"Current Developments in Nutrition\",\"volume\":\"9 7\",\"pages\":\"Article 107479\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-05-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Developments in Nutrition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2475299125029403\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Developments in Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2475299125029403","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

摘要

背景低碳水化合物饮食（LCD）模式已被研究为减少慢性炎症的潜在策略。证据仍然模棱两可，可能是因为LCD模式中碳水化合物来源的质量存在差异。目的前瞻性研究碳水化合物质量变化的LCD模式与炎症和氧化应激生物标志物的变化之间的关系。方法Framingham后代研究参与者(n = 2225；中位随访6.7年，平均基线年龄：60.1岁)，我们使用食物频率问卷创建了2个LCD评分（LCD）来衡量碳水化合物来源的质量。这反映了总脂肪和蛋白质的摄入量增加，而低质量碳水化合物[高质量lcd (HQ-LCDS)]或高质量碳水化合物[低质量lcd (LQ-LCDS)]的摄入量减少。我们通过将9种炎症和氧化应激生物标志物的标准化值相加来计算炎症和氧化应激评分。使用多变量线性回归模型估计LCDS五分位数类别中炎症和氧化应激评分的最小二乘平均变化，并对潜在混杂因素进行调整。结果shq - lcds与炎症和氧化应激评分变化呈负相关(Q1: 0.24±0.16,Q5:−0.27±0.16；Ptrend = 0.004)，说明炎症和氧化应激在低HQ-LCDS组中增加，在高HQ-LCDS组中减少。HQ-LCDS还与细胞间粘附分子-1 （Ptrend = 0.003）和脂蛋白磷脂酶A2活性（Ptrend = 0.003）的变化呈负相关。LQ-LCDS无显著相关性。结论：保留高质量碳水化合物，同时用脂肪和蛋白质替代低质量碳水化合物来源（如精制谷物和添加糖）的slcd模式与炎症和氧化应激评分呈负相关，可能降低慢性疾病风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Low-Carbohydrate Diet Patterns That Favor High-Quality Carbohydrates Are Associated with Beneficial Long-Term Changes in Biomarkers of Inflammation and Oxidative Stress in the Framingham Offspring Cohort

Background

Low-carbohydrate diet (LCD) patterns have been studied as a potential strategy to reduce chronic inflammation. Evidence remains equivocal, likely because of differences in the quality of carbohydrate sources among LCD patterns.

Objectives

To prospectively examine the associations between LCD patterns varying in carbohydrate quality, and changes of inflammation and oxidative stress biomarkers.

Methods

Among Framingham Offspring Study participants (n = 2225; median 6.7-y follow-up, mean baseline age: 60.1 y), we used food frequency questionnaires to create 2 LCD scores (LCDS) accounting for quality of carbohydrates sources. These reflected higher intake of total fat and protein, and lower intake of either low-quality carbohydrates [high-quality LCDS (HQ-LCDS)] or high-quality carbohydrates [low-quality LCDS (LQ-LCDS)]. We calculated an inflammation and oxidative stress score by summing the standardized values of 9 inflammatory and oxidative stress biomarkers. Least-square mean change in the inflammation and oxidative stress score across quintile categories of LCDS was estimated using multivariable linear regression models, adjusted for potential confounders.

Results

HQ-LCDS was inversely associated with change in the inflammation and oxidative stress score (mean ± SE in Q1: 0.24 ± 0.16, Q5: −0.27 ± 0.16; P_trend = 0.004), indicating that inflammation and oxidative stress increased in those in the lowest HQ-LCDS category and decreased in those in the highest category. HQ-LCDS was also inversely associated with changes in intercellular adhesion molecule-1 (P_trend = 0.003) and lipoprotein phospholipase A2 activity (P_trend = 0.003). No significant associations were observed for LQ-LCDS.

Conclusions

LCD patterns that preserved high-quality carbohydrates while replacing low-quality carbohydrates sources, such as refined grains and added sugars, with fat and protein were inversely associated with inflammation and oxidative stress score, potentially lowering chronic disease risk.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊