水生和陆地疗法在改善帕金森患者肌肉力量和形态参数方面无效：一项随机试验

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-06-13 DOI:10.1016/j.clinbiomech.2025.106594

Bruno Strey , Jéssica Saccol Borin Aita , Bruna Frata , Fernanda Cechetti , Ronei Silveira Pinto

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引用次数: 0

摘要

本研究旨在探讨两种常见的保守物理治疗方式：水上疗法和陆上疗法对帕金森病患者疾病进展和客观神经肌肉和形态学参数的影响。方法一项随机临床试验纳入30名帕金森病患者，分为水上疗法和陆上疗法两组，为期12周。主要终点是统一帕金森病评定量表（UPDRS）第三部分。膝关节等距力发展率和等距峰值扭矩采用动力测量法测量。通过DXA评估股骨骨密度、无脂量和脂肪量，超声评估股四头肌厚度、股四头肌比张力、大腿比张力和股四头肌回声强度。研究结果：在UPDRS、等速力发展率、等速峰值扭矩、骨密度或脂肪量方面，水上治疗组和陆地治疗组均未显示出显著变化。然而，两组的无脂质量均显著降低（p = 0.008）。与陆上治疗（Δ =−1.8±9.1任意单位）相比，水上治疗组显著增加股直肌回波强度（Δ = 8.1±14.8任意单位）。几个等距力发展速率间隔以及股四头肌比张力和大腿比张力与UPDRS显著相关(p <；0.05)。两种低强度训练方式都不能改善帕金森病患者的力量产生，但可以减少大腿无脂肪量。帕金森病的进展与力产生参数显著相关，而不是形态学参数。

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Aquatic and land-based therapies were ineffective in improving muscle strength and morphological parameters in Parkinson: A randomized trial

Background

This study aims to investigate the efficacy of two common conservative physical therapy modalities: aquatic-based therapy and land-based therapy on disease progression and objective neuromuscular and morphological parameters in individuals with Parkinson's disease.

Methods

A randomized clinical trial involved 30 participants with Parkinson's disease, assigned to either aquatic-based therapy or land-based therapy for 12 weeks. The primary outcome was the Unified Parkinson's Disease Rating Scale (UPDRS), Section III. Knee isometric rate of force development and isokinetic peak torque were measured using dynamometry. Thigh bone mass density, fat-free mass, and fat mass were assessed via DXA, while ultrasonography evaluated quadriceps muscle thickness, quadriceps specific tension, thigh specific tension, and echo intensity of the quadriceps.

Findings

Neither the aquatic-based therapy nor land-based therapy groups showed significant changes in the UPDRS, isometric rate of force development, isokinetic peak torque, bone mass density, or fat mass. However, both groups exhibited a significant reduction in fat-free mass (p = 0.008). The aquatic-based therapy group significantly increased echo intensity of the rectus femoris (Δ = 8.1 ± 14.8 arbitrary units) compared to land-based therapy (Δ = −1.8 ± 9.1 arbitrary units). Several isometric rate of force development intervals and both quadriceps specific tension and thigh specific tension were significantly related to the UPDRS (p < 0.05).

Interpretation

Both low-intensity modalities did not improve force production but reduced thigh fat-free mass in individuals with Parkinson's disease. Parkinson's disease progression was significantly associated with force production parameters rather than morphological parameters.

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.