Benedikt Nißl, Dr. Marcel Mülbaier, Prof. Dr. Francesca Grisoni, Prof. Dr. Dirk Trauner, Prof. Dr. Marcel Bermúdez, Dr. Clemens Dialer, Prof. Dr. David B. Konrad
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The Chemistry and Biology of the Tetrodotoxin Natural Product Family
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity. This review highlights the diversity of the tetrodotoxin natural product family and discusses the origins of derivatives, biosynthetic hypotheses, and biological activities. Furthermore, potential therapeutic applications and structure–activity relationship studies are covered, along with the total syntheses of the natural product and selected derivatives that were published to date.
期刊介绍：
Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.
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