三联体酮催化马来酰亚胺功能化硫苯甲醚。

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-06-18 DOI:10.1021/acs.joc.5c00794

Akash Bisoyi,Ramsiya Poolamanna,Alisha Rani Tripathy,Veera Reddy Yatham

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引用次数: 0

摘要

考虑到含硫有机分子在各个化学领域的重要性，本文报道了一种通过三联体酮催化α-C(sp3)-H功能化硫代苯胺与马来酰亚胺催化合成三环杂环的非对映选择性方案。温和的反应条件，廉价的光催化剂，分子氧作为末端氧化剂，以及与各种官能团的相容性是该方案的优点。初步的机理研究表明，在我们的反应条件下α-硫代烷基自由基的产生和空气氧的参与。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Triplet Ketone Catalysis-Enabled Functionalization of Thioanisoles with Maleimides.

Considering the importance of sulfur-containing organic molecules in various domains of chemistry, we report herein a protocol for the catalytic diastereoselective synthesis of tricyclic heterocycles through α-C(sp3)-H functionalization of thioanisoles with maleimides enabled by triplet ketone catalysis. Mild reaction conditions, an inexpensive photocatalyst, molecular oxygen as a terminal oxidant, and compatibility with various functional groups are advantages of the protocol. Preliminary mechanistic studies suggest the generation of α-thioalkyl radicals and involvement of aerial oxygen in our reaction conditions.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.