干细胞来源的细胞外囊泡在皮肤抗衰老治疗中的应用。

IF 15.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

ACS Nano Pub Date : 2025-06-17 DOI:10.1021/acsnano.4c17406

Ji Yeong Park,Se Young Jung,Donghyeon Yoo,Sihun Lee,Dabin Go,Van Dat Bui,Won-Kyo Jung,Dong Gil You,Jae Hyung Park,Wooram Um

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引用次数: 0

摘要

随着全球人口年龄中位数的上升和美容需求的增加，人们对抗衰老皮肤技术的兴趣也在显著增长。本文首先阐述了皮肤衰老的分子机制，然后概述了传统的抗衰老方法及其优点和局限性。此外，它强调了间充质干细胞衍生的细胞外囊泡（msc - ev）作为解决传统策略缺点的有希望的替代方案的潜力。本文重点介绍了msc - ev在皮肤微环境中的抗衰老作用和治疗机制，并基于msc - ev的功能特性确定了有前景的皮肤抗衰老干预靶点。最后，综述了基于msc - ev的抗衰老策略的最新进展和未来发展方向。

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Stem Cell-Derived Extracellular Vesicles in Skin Antiaging Treatments.

As the median age of the global population rises and the demand for aesthetic enhancement increases, interest in antiaging skin technologies has been growing significantly. This review first addresses the molecular mechanisms underlying skin aging, followed by an overview of traditional antiaging approaches and their benefits and limitations. Furthermore, it emphasizes the potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) as promising alternatives to address the shortcomings of conventional strategies. This article highlights the antiaging effects and therapeutic mechanisms of MSC-EVs in the skin microenvironment and identifies promising targets for skin antiaging interventions based on the functional properties of MSC-EVs. Finally, this review introduces the recent advances and future directions for MSC-EV-based antiaging strategies.

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来源期刊

ACS Nano 工程技术-材料科学：综合

CiteScore

26.00

自引率

4.10%

发文量

1627

审稿时长

1.7 months

期刊介绍： ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.