东伦敦帕金森氏病项目-帕金森氏病在不同人群中的病例对照研究。

IF 8.2 1区 医学 Q1 NEUROSCIENCES
Alexandra Zirra,Kamalesh C Dey,Ellen Camboe,Sheena Waters,Tahrina Haque,Brook Huxford,Harneek Chohan,Natalie Donkor,Joshua Kahan,Aaron Ben-Joseph,David A Gallagher,Caroline Budu,Thomas Boyle,Cristina Simonet,Andrew J Lees,Charles R Marshall,Alastair J Noyce
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引用次数: 0

摘要

在英国,来自代表性不足的少数民族的帕金森病(PD)患者的研究相对缺乏。东伦敦帕金森病项目旨在了解不同人群中帕金森病的临床表现和决定因素。在2019年至2024年期间收集了临床特征数据。我们评估了218名PD患者和90名对照组。其中,50%的患者和64%的对照组是南亚人或黑人。南亚和黑人患者的运动评分明显低于白人患者(平均[SD], 42.2[18.8]和47.0 [16.6]vs 35.2 [16.4], p < 0.001和p < 0.001)。认知障碍在南亚患者(73%)和黑人患者(75%)中比白人患者(45%,p = 0.002)更为普遍。我们的研究结果表明,与白人患者相比,南亚和黑人PD患者可能有更严重的运动和某些非运动特征,包括认知障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The East London Parkinson's disease project - a case-control study of Parkinson's Disease in a diverse population.
There is a relative dearth of research on patients with Parkinson's disease (PD) from under-represented ethnic groups in the United Kingdom. The East London Parkinson Disease project seeks to understand the clinical manifestations and determinants of PD in a diverse population. Data on clinical features were collected, between 2019 and 2024. We assessed 218 patients with PD and 90 controls. Among them, 50% of patients and 64% controls identified as South Asian or Black. South Asian and Black patients had significantly worse motor scores compared to White patients (mean [SD], 42.2 [18.8], and 47.0 [16.6] vs 35.2 [16.4], p < 0.001 and p < 0.001). Cognitive impairment was more prevalent in South Asian (73%) and Black patients (75%) than in White patients (45%, p = 0.002). Our results suggest that patients with PD from South Asian and Black ethnic groups may have more severe motor and certain non-motor features, including cognitive impairment, compared to White patients.
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来源期刊
NPJ Parkinson's Disease
NPJ Parkinson's Disease Medicine-Neurology (clinical)
CiteScore
9.80
自引率
5.70%
发文量
156
审稿时长
11 weeks
期刊介绍: npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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