Lin Shaoyong, Huanxiang Huang, Mingyue Wang, Jun Li, Yuhui Chen, Shousen Wang
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Malignant transformation of pituitary adenoma to carcinosarcoma: illustrative case.
Background: Carcinosarcomatous transformation is a rare complication following radiotherapy for pituitary adenomas (PAs).
Observations: The authors report what they believe to be the first case of a benign nonfunctioning PA developing into a carcinosarcoma after surgery and radiotherapy.
Lessons: Radiotherapy for PAs should account for the risk of secondary intracranial tumors, with long-term follow-up recommended for treated patients. Combined therapeutic strategies may be considered for radiation-induced sarcomas, and comprehensive molecular pathological studies of radiation-induced tumors are imperative for advancing understanding and management. https://thejns.org/doi/10.3171/CASE24765.
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