可逆性痴呆伴嗜酸性粒细胞增多:一个复杂的联系。

IF 1.3 Q3 MEDICINE, GENERAL & INTERNAL
Cureus Pub Date : 2025-06-14 eCollection Date: 2025-06-01 DOI:10.7759/cureus.86009
Ajay Emani, Ramakant Yadav, Roopesh Kirar, Midhun Mohan
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引用次数: 0

摘要

高嗜酸性粒细胞综合征(HES)是一种罕见的以嗜酸性粒细胞水平升高为特征的疾病,导致组织浸润和损伤。半数以上的患者出现神经系统并发症。这个案例研究讨论了一个45岁的男性患者诊断为HES和快速进行性痴呆。患者表现为日常工作困难、注意力缺陷、记忆力减退和额部头痛,持续一年。病史包括过敏性鼻炎和类湿疹皮损。一般和神经学检查显示高级精神功能缺陷,但无其他异常。实验室检查显示明显的嗜酸性粒细胞增多,脑磁共振成像(MRI)显示弥漫性皮质萎缩和心室周围高信号。临床和实验室结果支持HES的诊断。该病例强调了在患有不明原因的神经系统症状和嗜酸性粒细胞增多症的患者中考虑HES以防止不可逆器官损害的重要性。早期识别和适当管理对改善患者预后至关重要。这项研究强调了进一步研究了解HES的病理生理和开发靶向治疗的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Reversible Dementia With Hypereosinophilia: An Intricate Connection.

Hypereosinophilic syndrome (HES) is a rare group of disorders characterized by elevated eosinophil levels, leading to tissue infiltration and damage. Neurological complications are observed in over half of the patients. This case study discusses a 45-year-old male patient diagnosed with HES and rapidly progressive dementia. The patient presented with difficulties in routine tasks, attention deficits, memory loss, and frontal headaches lasting one year. His medical history included allergic rhinitis and eczematoid skin lesions. General and neurological examinations revealed deficits in higher mental functions without other abnormalities. Laboratory tests showed significant eosinophilia, and magnetic resonance imaging (MRI) of the brain indicated diffuse cortical atrophy and periventricular hyperintensities. The diagnosis of HES was supported by clinical and laboratory findings. The case highlights the importance of considering HES in patients with unexplained neurological symptoms and eosinophilia to prevent irreversible organ damage. Early recognition and appropriate management are crucial for improving patient outcomes. This study underscores the need for further research to understand HES's pathophysiology and develop targeted therapies.

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