{"title":"先锋转录因子双管齐下促进内皮细胞分化。","authors":"","doi":"10.1038/s44161-025-00661-x","DOIUrl":null,"url":null,"abstract":"Single-cell analyses defined the mechanisms by which the pioneer transcription factor ETV2 drives endothelial cell specification from mesodermal progenitors in vitro. ETV2 interaction with a transcription factor (GABPA) promoted endothelial cells differentiation, and ETV2 interaction with a repressor (REST) inhibited differentiation to alternative cell types.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 6","pages":"657-658"},"PeriodicalIF":10.8000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pioneer transcription factor two-pronged way to promote endothelial cell differentiation\",\"authors\":\"\",\"doi\":\"10.1038/s44161-025-00661-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Single-cell analyses defined the mechanisms by which the pioneer transcription factor ETV2 drives endothelial cell specification from mesodermal progenitors in vitro. ETV2 interaction with a transcription factor (GABPA) promoted endothelial cells differentiation, and ETV2 interaction with a repressor (REST) inhibited differentiation to alternative cell types.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 6\",\"pages\":\"657-658\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-06-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00661-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00661-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Pioneer transcription factor two-pronged way to promote endothelial cell differentiation
Single-cell analyses defined the mechanisms by which the pioneer transcription factor ETV2 drives endothelial cell specification from mesodermal progenitors in vitro. ETV2 interaction with a transcription factor (GABPA) promoted endothelial cells differentiation, and ETV2 interaction with a repressor (REST) inhibited differentiation to alternative cell types.
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