有丝分裂和减数分裂中分离酶活性控制的细微差别。

IF 9.8 1区生物学 Q1 Agricultural and Biological Sciences

PLoS Biology Pub Date : 2025-06-16 eCollection Date: 2025-06-01 DOI:10.1371/journal.pbio.3003206

Martin Anger

引用次数: 0

摘要

哺乳动物卵母细胞容易发生染色体分离错误，这往往导致非整倍体和妊娠流产。PLOS Biology上的一项新研究解决了Mad2/SGO2复合物在减数分裂期间控制这些细胞分离酶活性中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nuances in the control of separase activity between mitosis and meiosis.

Mammalian oocytes are prone to chromosome segregation errors, which frequently lead into aneuploidy and pregnancy loss. A new study in PLOS Biology addresses the role of the Mad2/SGO2 complex in the control of separase activity in these cells during meiosis.

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来源期刊

PLoS Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOLOGY

CiteScore

15.40

自引率

2.00%

发文量

359

审稿时长

3-8 weeks

期刊介绍： PLOS Biology is the flagship journal of the Public Library of Science (PLOS) and focuses on publishing groundbreaking and relevant research in all areas of biological science. The journal features works at various scales, ranging from molecules to ecosystems, and also encourages interdisciplinary studies. PLOS Biology publishes articles that demonstrate exceptional significance, originality, and relevance, with a high standard of scientific rigor in methodology, reporting, and conclusions. The journal aims to advance science and serve the research community by transforming research communication to align with the research process. It offers evolving article types and policies that empower authors to share the complete story behind their scientific findings with a diverse global audience of researchers, educators, policymakers, patient advocacy groups, and the general public. PLOS Biology, along with other PLOS journals, is widely indexed by major services such as Crossref, Dimensions, DOAJ, Google Scholar, PubMed, PubMed Central, Scopus, and Web of Science. Additionally, PLOS Biology is indexed by various other services including AGRICOLA, Biological Abstracts, BIOSYS Previews, CABI CAB Abstracts, CABI Global Health, CAPES, CAS, CNKI, Embase, Journal Guide, MEDLINE, and Zoological Record, ensuring that the research content is easily accessible and discoverable by a wide range of audiences.