探讨50岁以上男性精索静脉曲张与睾酮缺乏的关系。

IF 2.1 3区医学 Q2 UROLOGY & NEPHROLOGY

Urology Pub Date : 2025-06-14 DOI:10.1016/j.urology.2025.06.029

Daniel J Kim, Patrick E Teloken, John P Mulhall

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引用次数: 0

摘要

目的：探讨精索静脉曲张（VX）对老年男性总睾酮（TT）水平的影响。方法：回顾性分析部门数据库，评估年龄≥50岁，有两个睾丸的患者，并记录清晨TT水平。还分析了患者人口统计学、合并症、VX侧位和VX分级。结果：776例患者资料可查。平均年龄66±12岁。140例（18%）患者至少有一次VX检查（VX+）。其中118例（84%）单侧VX， 22例（16%）双侧VX。VX+组的平均TT （336 ng/dl±168）显著低于VX-组（472ng/ dl±267）(结论：在50岁以上的男性人群中，VX的存在、侧边性和分级与较低的TT水平相关。

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Exploring the Association Between Varicocele and Testosterone Deficiency in Men Over 50 Years of Age.

Objective: To define the impact of varicoceles (VX) on total testosterone (TT) levels in an aging male population.

Methods: This retrospective analysis of a departmental database assessed patients ≥50 years of age, who had two testes, and recorded early morning TT levels. Patient demographics, comorbidity profiles, VX laterality, and VX grade were also analyzed.

Results: Data was retrievable for 776 patients. Mean age was 66 ±12 years. 140 (18%) patients had at least one VX on examination (VX+). Of these 118 (84%) had unilateral VX while 22 (16%) had bilateral. Mean TT for the VX+ group (336 ng/dl ±168) was statistically significantly lower than for the VX- group (472ng/dL ±267) (p<0.01). Those with bilateral VX had lower TT (297 ng/dL) than those with unilateral VX (372 ng/dL) (p<0.05). While 16% of the total VX+ population had TT levels <300 ng/dl, these rates were 11% and 24% in men with unilateral and bilateral VX (p<0.01). In those with unilateral VX, there was a relationship between VX grade and testosterone deficiency, with the highest likelihood associated with Grade III (r=0.65, p<0.01). There was no association between Grade I and low T levels.

Conclusions: In this population of men older than 50, the presence, laterality and grade of VX were associated with lower levels of TT.

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来源期刊

Urology 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

9.50%

发文量

716

审稿时长

59 days

期刊介绍： Urology is a monthly, peer–reviewed journal primarily for urologists, residents, interns, nephrologists, and other specialists interested in urology The mission of Urology®, the "Gold Journal," is to provide practical, timely, and relevant clinical and basic science information to physicians and researchers practicing the art of urology worldwide. Urology® publishes original articles relating to adult and pediatric clinical urology as well as to clinical and basic science research. Topics in Urology® include pediatrics, surgical oncology, radiology, pathology, erectile dysfunction, infertility, incontinence, transplantation, endourology, andrology, female urology, reconstructive surgery, and medical oncology, as well as relevant basic science issues. Special features include rapid communication of important timely issues, surgeon''s workshops, interesting case reports, surgical techniques, clinical and basic science review articles, guest editorials, letters to the editor, book reviews, and historical articles in urology.