重新考察一些土着土耳其羊种群的遗传背景:瓶颈和迁移。

IF 1.7 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Bahar Argun Karsli, Eymen Demir, Umit Bilginer, Murat Soner Balcioğlu, Taki Karsli
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引用次数: 0

摘要

本研究旨在研究土耳其4个地方绵羊品种g neykaraman (GKR)、karakaku (KRK)、Kangal (KNG)和Norduz (NRD)的遗传瓶颈效应和迁移事件。通过对120只动物28个高度多态性微卫星位点进行基因分型,采用不同突变模型下的Wilcoxon检验评估遗传瓶颈,并采用TreeMix算法研究种群分裂和迁移事件。基于两阶段突变模型(TPM)的Wilcoxon符号秩检验和基于等位基因频率分布的模式转移指标表明,4个安纳托利亚绵羊品种不存在遗传瓶颈。这一发现表明,所研究的绵羊品种在最近的过去保持了它们的有效种群规模。同样,有效种群大小的估计值高于采样动物的数量,表明它们是具有更高样本量的祖先种群的后代。TreeMix算法显示,NRD与其他品种存在遗传差异,而NRD向KRK和GKR的迁移率为0.0096。KNG品种向GKR品种的迁移率最高(0.0176)。这项研究的结果有望帮助育种者采取必要的预防措施,以实现未来的可持续生产,并促进正在进行的保护计划。事实上,育种者被鼓励利用微卫星和高通量基因组工具,如SNP阵列和下一代测序技术,来预测当地绵羊群体的有效群体规模和遗传瓶颈效应的趋势。此外,在保护计划中应考虑对NRD品种进行地理隔离和纯种繁殖,以消除近交萧条和遗传瓶颈。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Re-visiting genetic background of some native Turkish sheep populations: bottleneck and migration.

This study aimed to investigate genetic bottleneck effects and migration events among four native Turkish sheep breeds, namely Güney Karaman (GKR), Karakaş (KRK), Kangal (KNG), and Norduz (NRD). After genotyping a total of 120 animals with 28 highly polymorphic microsatellite loci, the genetic bottleneck was assessed by the Wilcoxon test under different mutation models, while population splits and migration events were investigated by the TreeMix algorithm. Wilcoxon sign rank test under the two-phased mutation model (TPM) and the mode-shift indicator based on the distribution of allele frequencies evidenced a lack of genetic bottleneck in four Anatolian sheep breeds. This finding implies that the studied sheep breeds have maintained their effective population size in the recent past. Similarly, the estimated values of effective population size were higher than the number of sampled animals, indicating that they were descendants of ancestral populations with higher sample sizes. The TreeMix algorithm revealed that the NRD was genetically distinct from the other breeds, while there was migration from NRD to KRK and GKR with a rate of 0.0096. The highest migration rate (0.0176) was detected from the KNG to the GKR breed. The results of this study are expected to assist breeders in taking necessary precautions for sustainable production in the future and to facilitate ongoing conservation programs. Indeed, breeders are encouraged to utilize both microsatellites and high-throughput genomic tools such as SNP arrays and next-generation sequencing technologies to foresee the trend in effective population size and genetic bottleneck effects in local sheep populations. Besides, geographic isolation and pure breeding of the NRD breed should be considered in conservation programs to eliminate inbreeding depression and genetic bottleneck in the future.

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来源期刊
Tropical animal health and production
Tropical animal health and production 农林科学-兽医学
CiteScore
3.40
自引率
11.80%
发文量
361
审稿时长
6-12 weeks
期刊介绍: Tropical Animal Health and Production is an international journal publishing the results of original research in any field of animal health, welfare, and production with the aim of improving health and productivity of livestock, and better utilisation of animal resources, including wildlife in tropical, subtropical and similar agro-ecological environments.
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