Eline C Jager, James McNeil, Alexander J Papachristos, Mark Sywak, Stan B Sidhu, Rhonda Siddall, Jeremy Hoang, Geoffrey P Schembri, Venessa H M Tsang, Ayanthi Wijewardene, Lyndal Tacon, Bruce Robinson, Roderick J Clifton-Bligh, Martyn Bullock, Adrienne H Brouwers, Thera P Links, Schelto Kruijff, Anthony R Glover, Matti L Gild
{"title":"68Ga-DOTATATE和18F-FDG PET/CT在预测晚期甲状腺髓样癌患者对酪氨酸激酶抑制剂的反应中的应用","authors":"Eline C Jager, James McNeil, Alexander J Papachristos, Mark Sywak, Stan B Sidhu, Rhonda Siddall, Jeremy Hoang, Geoffrey P Schembri, Venessa H M Tsang, Ayanthi Wijewardene, Lyndal Tacon, Bruce Robinson, Roderick J Clifton-Bligh, Martyn Bullock, Adrienne H Brouwers, Thera P Links, Schelto Kruijff, Anthony R Glover, Matti L Gild","doi":"10.1186/s13044-025-00250-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of patients with advanced medullary thyroid cancer (MTC). However, treatment response heterogeneity leads to challenges in predicting individual favourable response. This study evaluated the correlation between PET metrics on <sup>68</sup>Ga-DOTATATE and <sup>18</sup>F-FDG PET/CTs prior to treatment, and TKI response.</p><p><strong>Methods: </strong>This study retrospectively evaluated patients with metastatic MTC who received TKIs at a tertiary care hospital and had prior <sup>68</sup>Ga-DOTATATE and/or <sup>18</sup>F-FDG PET/CT imaging. Patient demographics, treatment and PET/CT data were collected. Standardized Uptake Value (SUV) max, SUVmean, Total Lesion Activity (TLA) and Metabolic Tumor Volume (MTV) were determined per PET/CT.</p><p><strong>Results: </strong>In the 25 patients, mean age at diagnosis was 48 (±15) years; 11 (44%) were female and 21 tumors harbored RET driver alterations. Thirty-six TKI treatments were administered (11 patients received two TKIs sequentially). RECIST response rates (available in 32/36 treatments) included; stable disease in 8/32 (25%), partial response in 23/32 (72%) and complete response in 1/32 (3%) treatments. In total, 30 pre-TKI PET/CTs (24 <sup>68</sup>Ga-DOTATATE PET/CTs, 6 <sup>18</sup>F-FDG PET/CTs) were performed. Pre-TKI <sup>68</sup>Ga-DOTATATE PET/CTs did not correlate with TKI treatment response. In the <sup>18</sup>F-FDG cohort, high MTV and TLA correlated with a better structural response (p < 0.001) and high SUVmean correlated with a longer time to reach optimal response (p = 0.037).</p><p><strong>Conclusions: </strong>In a small cohort of MTC patients, MTV and TLA on <sup>18</sup>F-FDG PET/CT were associated with the structural response of TKI treatment, suggesting their potential utility in identifying patients who are likely to respond significantly. In contrast, TKI response showed no correlation with uptake on <sup>68</sup>Ga-DOTATATE PET/CT.</p>","PeriodicalId":39048,"journal":{"name":"Thyroid Research","volume":"18 1","pages":"31"},"PeriodicalIF":1.9000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172355/pdf/","citationCount":"0","resultStr":"{\"title\":\"The utility of <sup>68</sup>Ga-DOTATATE and <sup>18</sup>F-FDG PET/CT in predicting the response to tyrosine kinase inhibitors in patients with advanced medullary thyroid cancer.\",\"authors\":\"Eline C Jager, James McNeil, Alexander J Papachristos, Mark Sywak, Stan B Sidhu, Rhonda Siddall, Jeremy Hoang, Geoffrey P Schembri, Venessa H M Tsang, Ayanthi Wijewardene, Lyndal Tacon, Bruce Robinson, Roderick J Clifton-Bligh, Martyn Bullock, Adrienne H Brouwers, Thera P Links, Schelto Kruijff, Anthony R Glover, Matti L Gild\",\"doi\":\"10.1186/s13044-025-00250-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of patients with advanced medullary thyroid cancer (MTC). However, treatment response heterogeneity leads to challenges in predicting individual favourable response. This study evaluated the correlation between PET metrics on <sup>68</sup>Ga-DOTATATE and <sup>18</sup>F-FDG PET/CTs prior to treatment, and TKI response.</p><p><strong>Methods: </strong>This study retrospectively evaluated patients with metastatic MTC who received TKIs at a tertiary care hospital and had prior <sup>68</sup>Ga-DOTATATE and/or <sup>18</sup>F-FDG PET/CT imaging. Patient demographics, treatment and PET/CT data were collected. Standardized Uptake Value (SUV) max, SUVmean, Total Lesion Activity (TLA) and Metabolic Tumor Volume (MTV) were determined per PET/CT.</p><p><strong>Results: </strong>In the 25 patients, mean age at diagnosis was 48 (±15) years; 11 (44%) were female and 21 tumors harbored RET driver alterations. Thirty-six TKI treatments were administered (11 patients received two TKIs sequentially). RECIST response rates (available in 32/36 treatments) included; stable disease in 8/32 (25%), partial response in 23/32 (72%) and complete response in 1/32 (3%) treatments. In total, 30 pre-TKI PET/CTs (24 <sup>68</sup>Ga-DOTATATE PET/CTs, 6 <sup>18</sup>F-FDG PET/CTs) were performed. Pre-TKI <sup>68</sup>Ga-DOTATATE PET/CTs did not correlate with TKI treatment response. In the <sup>18</sup>F-FDG cohort, high MTV and TLA correlated with a better structural response (p < 0.001) and high SUVmean correlated with a longer time to reach optimal response (p = 0.037).</p><p><strong>Conclusions: </strong>In a small cohort of MTC patients, MTV and TLA on <sup>18</sup>F-FDG PET/CT were associated with the structural response of TKI treatment, suggesting their potential utility in identifying patients who are likely to respond significantly. In contrast, TKI response showed no correlation with uptake on <sup>68</sup>Ga-DOTATATE PET/CT.</p>\",\"PeriodicalId\":39048,\"journal\":{\"name\":\"Thyroid Research\",\"volume\":\"18 1\",\"pages\":\"31\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172355/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Thyroid Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1186/s13044-025-00250-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Thyroid Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13044-025-00250-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
The utility of 68Ga-DOTATATE and 18F-FDG PET/CT in predicting the response to tyrosine kinase inhibitors in patients with advanced medullary thyroid cancer.
Background: Tyrosine kinase inhibitors (TKIs) have significantly improved the prognosis of patients with advanced medullary thyroid cancer (MTC). However, treatment response heterogeneity leads to challenges in predicting individual favourable response. This study evaluated the correlation between PET metrics on 68Ga-DOTATATE and 18F-FDG PET/CTs prior to treatment, and TKI response.
Methods: This study retrospectively evaluated patients with metastatic MTC who received TKIs at a tertiary care hospital and had prior 68Ga-DOTATATE and/or 18F-FDG PET/CT imaging. Patient demographics, treatment and PET/CT data were collected. Standardized Uptake Value (SUV) max, SUVmean, Total Lesion Activity (TLA) and Metabolic Tumor Volume (MTV) were determined per PET/CT.
Results: In the 25 patients, mean age at diagnosis was 48 (±15) years; 11 (44%) were female and 21 tumors harbored RET driver alterations. Thirty-six TKI treatments were administered (11 patients received two TKIs sequentially). RECIST response rates (available in 32/36 treatments) included; stable disease in 8/32 (25%), partial response in 23/32 (72%) and complete response in 1/32 (3%) treatments. In total, 30 pre-TKI PET/CTs (24 68Ga-DOTATATE PET/CTs, 6 18F-FDG PET/CTs) were performed. Pre-TKI 68Ga-DOTATATE PET/CTs did not correlate with TKI treatment response. In the 18F-FDG cohort, high MTV and TLA correlated with a better structural response (p < 0.001) and high SUVmean correlated with a longer time to reach optimal response (p = 0.037).
Conclusions: In a small cohort of MTC patients, MTV and TLA on 18F-FDG PET/CT were associated with the structural response of TKI treatment, suggesting their potential utility in identifying patients who are likely to respond significantly. In contrast, TKI response showed no correlation with uptake on 68Ga-DOTATATE PET/CT.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
