棘阿米巴角膜炎：对保守治疗有抵抗的患者进行角膜移植的最佳时机是什么？

IF 0.8 4区医学 Q4 OPHTHALMOLOGY

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2025-06-01 Epub Date: 2025-06-16 DOI:10.1055/a-2558-8878

Yaser Abu Dail, Elias Flockerzi, Nóra Szentmáry, Berthold Seitz, Loay Daas

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引用次数: 0

摘要

棘阿米巴角膜炎（AK）是由棘阿米巴引起的一种威胁视力的感染性角膜炎。及时和适当的保守治疗AK可导致角膜炎的治愈和良好的视力，在疾病的进一步过程中不需要角膜移植术。在治疗难治性病例中，强化抗阿米巴治疗（AAT）后的角膜移植术，即所谓的“低负荷角膜移植术”，似乎比主动延迟角膜移植术（光学/治疗）提供更好的总体预后和更早的视力和心理康复。需要进一步的研究直接比较早期和延迟角膜移植术，以更好地确定AK患者角膜移植的最佳时机。

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Acanthamoeba Keratitis: What is the Best Time for Keratoplasty in Patients with Resistance to Conservative Therapy?

Acanthamoebic keratitis (AK) is a sight-threatening infectious keratitis caused by Acanthamoeba. Timely and appropriate conservative treatment of AK can lead to a cure of the keratitis with good visual acuity, without the need for keratoplasty in the further course of the disease. In treatment-resistant cases, keratoplasty after intensive anti-amoebic therapy (AAT), so-called "low-load keratoplasty", appears to offer a better overall prognosis and earlier visual and psychological rehabilitation than actively delayed keratoplasty (optical/therapeutic). Further studies directly comparing early and delayed keratoplasty are needed to even better determine the optimal timing of corneal transplantation in AK.

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来源期刊

Klinische Monatsblatter fur Augenheilkunde 医学-眼科学

CiteScore

1.30

自引率

0.00%

发文量

235

审稿时长

4-8 weeks

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