Lens Morphology in Cataract Patients with Zonula Dialysis by Anterior Segment Optical Coherence Tomography.

Purpose: To investigate the morphologic characteristics of lens in cataract patients with zonule dialysis (ZD) before and after cycloplegia by anterior segment optical coherence tomography (AS-OCT).

Setting: Peking University Third Hospital, Beijing, China.

Design: Cross-sectional observational study.

Methods: 56 eyes from 56 participants who would undergo cataract operations were included, with 29 eyes of normal controls and 27 eyes of zonule dialysis patients. Lens morphologic parameters were then evaluated by AS-OCT, including anterior chamber depth (ACD), lens thickness (LT), lens diameter, lens vault, anterior curvature radius, posterior curvature radius, decentration and tilt of lens. After participants were treated with three-time tropicamide solution, AS-OCT was repeated to acquire the post-cycloplegia results. SPSS Software 22.0 was used for statistical analysis.

Results: The comparison of basic lens morphologic parameters without cycloplegia found only anterior curvature (P=0.039) showed significant differences between normal and ZD groups. AS-OCT measured after 30-min cycloplegia treatment showed significantly increased ACD, lens diameter, posterior curvature and decreased vault in both groups, decreased lens thickness in normal group, increased anterior curvature and decreased lens decentration in ZD group (all P<0.05). The logistic regression model showed ZD group had greater alterations of ACD (P=0.014), anterior curvature (P=0.009) and decentration (P=0.031) after cycloplegia treatment when compared with the normal group.

Conclusions: Lens in ZD patients was characterized by steeper anterior curvature, and grater alterations of ACD, anterior curvature and decentration after cycloplegia. The comparison of lens morphologic parameters before and after cycloplegia might be the potential method to evaluate the stability of zonule.