心源性休克的心脏和全身炎症。

IF 3.5 3区医学 Q1 CRITICAL CARE MEDICINE

Current Opinion in Critical Care Pub Date : 2025-08-01 Epub Date: 2025-05-21 DOI:10.1097/MCC.0000000000001286

Guillaume Théry, Nadia Aissaoui, Olfa Hamzaoui

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引用次数: 0

摘要

回顾的目的：在过去的几十年里，对心源性休克（CS）的理解有了显著的发展。CS最初被认为是一种纯粹的机制综合征，现在被认为是一种多方面的疾病，包括血流动力学损害和级联炎症反应的复杂相互作用。这篇综述的目的是描述心脏和全身炎症参与心源性休克。最近的发现：在CS患者中定义亚表型是强制性的，因为它不再被认为是一个同质的实体。因此，在风险分层方法中包括炎症生物标志物，并确定可预测对定制治疗有反应的人群是一个主要问题。摘要：在这篇综述中，我们提出了CS中发生的心脏和全身炎症的叙述性综述，炎症生物标志物的研究现状及其在风险分层中的意义，以及即将进行的针对炎症治疗的试验。

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Cardiac and systemic inflammation in cardiogenic shock.

Purpose of review: The understanding of cardiogenic shock (CS) has significantly evolved over the past decades. Initially regarded as a purely mechanistic syndrome, CS is now recognized as a multifaceted condition that incorporates a complex interplay of hemodynamic compromise and a cascading inflammatory response. This review aims to describing cardiac and systemic inflammation involvement in cardiogenic shock.

Recent findings: Defining subphenotypes among CS patients is mandatory as it is no longer considered as a homogeneous entity. Accordingly, including inflammatory biomarkers in a risk-stratification approach and identifying populations who will predictably respond to tailored therapies is a major concern.

Summary: In this review, we propose a narrative review on cardiac and systemic inflammation occurring in CS, current research on inflammatory biomarkers and their implications in risk-stratification, and upcoming trials on therapies targeting inflammation.

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来源期刊

Current Opinion in Critical Care 医学-危重病医学

CiteScore

5.90

自引率

3.00%

发文量

172

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Critical Care delivers a broad-based perspective on the most recent and most exciting developments in critical care from across the world. Published bimonthly and featuring thirteen key topics – including the respiratory system, neuroscience, trauma and infectious diseases – the journal’s renowned team of guest editors ensure a balanced, expert assessment of the recently published literature in each respective field with insightful editorials and on-the-mark invited reviews.