多能干细胞衍生的胰腺和肝细胞的微胶囊化：生物学需求和技术解决方案。

IF 5.8 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Biomaterials Science Pub Date : 2025-06-17 DOI:10.1039/d5bm00696a

Kianna Nguyen, Quang Tuan Che, Quoc Huynh Nguyen, Kihak Gwon, Alan Gonzalez Suarez, Gulnaz Stybayeva, Robert Huebert, Quinn Peterson, Alexander Revzin

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引用次数: 0

摘要

多能干细胞衍生产品是研究疾病和开发细胞疗法的通用工具。微胶囊技术为这些干细胞衍生产品的可扩展性、延长生存期和可移植性提供了解决方案。本文综述了目前用于干细胞封装的方法和材料。具体来说，干细胞来源的β细胞和肝细胞的分化进行了探索。这包括分化方案的现状，微胶囊分化和移植的例子，以及未来的方向。

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Microencapsulation of pluripotent stem cell-derived pancreatic and liver cells: biological needs and technological solutions.

Pluripotent stem cell-derived products are versatile tools for studying disease and developing cellular therapies. Microencapsulation technologies offer solutions for scalability, prolonged survival, and transplantability of these stem-cell derived products. This review describes current methods and materials utilized for stem cell encapsulation. Specifically, the differentiation of stem cell-derived β cells and hepatocytes is explored. This includes the current state of differentiation protocols, examples of microencapsulation for differentiation and transplantation, and future directions.

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.