前哨淋巴结活检对肢端黑色素瘤患者预后的影响

IF 3.6 4区医学 Q2 DERMATOLOGY

Anais brasileiros de dermatologia Pub Date : 2025-06-18 DOI:10.1016/j.abd.2025.501129

Thiago Francischetto , Ana Clara Falcão , Adson Santos Neves , Ana Beatriz Lira , Robson Freitas de Moura , Thiago Souza Oliveira Freitas de Moura , Juvandy Antonio Inacio Santos , André Bacellar Costa Lima , Marco Antonio Oliveira Lessa , Jussamara Britos Santos , Alexandre Farias de Albuquerque , Vaner Paulo da Silva Fonseca Pinheiro

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引用次数: 0

摘要

背景：黑色素瘤患者前哨淋巴结（SLN）活检在分期、预后评估和治疗定义中具有重要作用。很少有研究评估其在肢端黑色素瘤（AM）亚型中的作用。目的评价在同一肿瘤中心接受治疗的79例肢端黑色素瘤患者的SLN活检结果，并与文献中描述的数据进行比较。方法：2016年1月至2022年12月，作者分析了同一研究所所有接受SLN活检的AM患者。作者分析了流行病学、临床和组织病理学资料。总生存期（OS）和无病生存期（DFS）曲线采用Kaplan-Meier法估计。采用Cox回归模型进行多因素分析。结果在此期间，作者分析了79例。平均年龄60岁，中位厚度4.5 mm， 67.1%有溃疡。SLN阳性27例（34.2%）。估计OS和DFS分别为67.7%和45.2%。SLN阴性组OS优于SLN阳性组（70.9% vs. 53.2%），但差异无统计学意义（p = 0.08）。SLN阳性的估计DFS与预后明显较差相关（33.8 × 46.7%,p = 0.001）。研究局限性：本研究为回顾性研究，患者数量有限。结论本研究对判断预后有重要意义。与SLN阴性的患者相比，AM和SLN阳性的患者预后最差。

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Influence of sentinel lymph node biopsy on the prognosis of acral melanoma patients

Background

Sentinel lymph node (SLN) biopsy in melanoma patients has an important role in staging, prognosis assessment, and treatment definition. Few studies have evaluated its role in the Acral Melanoma (AM) subtype.

Objective

To evaluate the results of SLN biopsy in 79 patients with acral melanoma treated at a single oncological center and compare them with the data described in the literature.

Methods

Between January 2016 and December 2022, the authors analyzed all patients with AM who underwent SLN biopsy in a single institute. The authors analyzed the epidemiological, clinical and histopathological data. Overall Survival (OS) and Disease-Free Survival (DFS) curves were estimated using the Kaplan-Meier method. Multivariate analyses were conducted using the Cox regression model.

Results

During the period, the authors analyzed 79 cases. The mean age was 60 years and median thickness was 4.5 mm and 67.1% had ulceration. SLN was positive in 27 patients (34.2%). The estimated OS and DFS were 67.7% and 45.2%. OS was better in the negative SLN group compared to the positive SLN group (70.9% vs. 53.2%), but without statistical significance (p = 0.08). Estimated DFS for positive SLN was associated with a significantly worse prognosis (33.8 × 46.7%, p = 0.001).

Study limitations

The retrospective nature of the study and the limited number of patients.

Conclusions

The present study has significant implications for determining prognosis. Patients with AM and positive SLN had a worst prognosis compared to those with negative SLN.

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来源期刊

Anais brasileiros de dermatologia DERMATOLOGY-

CiteScore

2.40

自引率

0.00%

发文量

184

审稿时长

32 days

期刊介绍： The journal is published bimonthly and is devoted to the dissemination of original, unpublished technical-scientific study, resulting from research or reviews of dermatological topics and related matters. Exchanges with other publications may be accepted.