中药口服给药用海藻酸钠/羧甲基壳聚糖/明胶柚皮素ph响应水凝胶珠

IF 10.7 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-06-11 DOI:10.1016/j.carbpol.2025.123870

Zixing Yan , Qingling Nie , Jiajia Liu , Jingxin Chen , Youmei Liu , Yudong Lu , Mengjun Xu , Zhenwen Lin

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引用次数: 0

摘要

胃疾病是一种常见的消化系统疾病。随着人们对传统医学的日益重视，使用草药治疗胃病引起了人们的广泛关注。然而，直接服用半衰期短的中草药导致药物利用率低。为了解决这一问题，本研究设计了海藻酸钠/羧甲基壳聚糖/明胶柚皮素（SA/CMCh/Gel-Nar）组成的ph响应型复合水凝胶珠，用于包封草药马鞍煎剂（AZD）作为胃肠道疾病的缓释药物。SA/CMCh/Gel-Nar水凝胶珠具有载药量大、黏附力强（98.33%保留率）、ph响应缓释性能好等特点。在SGF中，39%的药物在2 h内释放，确保了快速的治疗效果，而在SIF中，其余61%的药物在23 h内逐渐释放。这些水凝胶珠具有优异的抗菌功效（> 93.4%）和高生物安全性（细胞存活率>； 97.21%），为药物在胃肠道的持续传递提供了一个有前景的安全平台。

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Sodium alginate/carboxymethyl chitosan/gelatin-naringenin pH-responsive hydrogel beads for oral delivery of traditional Chinese herbal medicines

Stomach disorders are a common category of digestive system diseases. With the increasing emphasis on traditional medicine, the use of herbal medicines in treating gastric diseases has attracted much attention. However, direct administration of herbal medicines with short half-life leads to low drug utilization. To address this problem, pH-responsive composite hydrogel beads consisting of sodium alginate/carboxymethyl chitosan/gelatin-naringenin (SA/CMCh/Gel-Nar) were designed in this study to encapsulate decocted herbal saddle decoctions (AZD) for use as sustained-release medications for gastrointestinal disorders. The SA/CMCh/Gel-Nar hydrogel beads have high drug loading capacity, strong adhesion (98.33 % retention), and excellent pH-responsive sustained-release properties. In SGF, 39 % of the drug was released within 2 h, ensuring rapid therapeutic efficacy, while in SIF, the remaining 61 % was gradually released within 23 h. With excellent antimicrobial efficacy (>93.4 %) and high biosafety (cell viability >97.21 %), these hydrogel beads provide a promising and safe platform for sustained drug delivery in the gastrointestinal tract.

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.