儿童过敏性疾病的暴露研究：ECHO-COCOA研究的基本原理和设计

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-06-18 DOI:10.1016/j.ecoenv.2025.118533

Song-I Yang , Hosub Im , Yanghee Kim , Hyo-Bin Kim , Jeong-Hyun Kim , Jeonghun Yeom , Hyun Ju Yoo , Mi Jeong Kim , Hoon Je Seong , Hea Young Oh , Yong Joo Park , Mi-Jin Kang , Seung-Hwa Lee , Hwan-Cheol Kim , Sung-Ok Kwon , Kyung-Sook Lee , Yee-Jin Shin , Jisun Yoon , Eom ji Choi , Youn Ho Shin , Soo-Jong Hong

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引用次数: 0

摘要

综合考虑环境暴露的总量和由此产生的内源性反应在评估早期生活暴露对儿童健康的影响方面起着至关重要的作用。儿童哮喘和过敏性疾病起源的暴露体和儿童健康组学队列（ECHO-COCOA）研究是基于COCOA出生队列进行的，这是一项基于一般人群的队列研究，旨在评估韩国环境暴露的多组学特征及其对儿童过敏性疾病、肥胖和神经发育的影响。方法对481对母子进行了156种化学污染物和多组学分析（甲基组、基因组、肠道微生物组、转录组、代谢组、蛋白质组和多重细胞因子分析）。我们之前的研究使用组学分析揭示了儿童过敏性疾病的机制。使用综合多组学方法研究早期生活环境暴露、组学和各种儿童内源性过敏性疾病之间的复杂相互作用正在进行中。ECHO-COCOA研究将在未来进一步发展，增加样本量，使用先进的暴露测量方法，整合不同的组学技术，并开发新的统计方法。与其他出生队列研究或外部验证的合作和整合将有助于推进ECHO-COCOA研究。结论本研究的发现可能促进精准医学的发展，以及基于有害暴露的过敏性疾病、肥胖和神经发育的预防，特别是在生命的关键时期。

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Exposome study for allergic diseases in children: Rationale and design of ECHO-COCOA study

Background

Comprehensive consideration of the totality of environmental exposures and the resulting endogenous responses plays a crucial role in assessing the effect of early-life exposure on child health.

Objectives

The Exposome and Child Health with Omics-COhort for Childhood Origin of Asthma and allergic diseases (ECHO-COCOA) study was conducted based on the COCOA birth cohort, a general population-based cohort study that aimed to evaluate multi-omics signatures of environmental exposures and their effect on childhood allergic diseases, obesity and neurodevelopment in Korea.

Methods

In total, 156 chemical pollutants and multi-omics profiles (methylome, genome, gut microbiome, transcriptome, metabolome, proteome, and multiplex cytokine assay) were investigated in 481 mother-child pairs. Our previous studies using omics analysis revealed the mechanisms of childhood allergic diseases. Studies on the complex interactions between early-life environmental exposures, omics, and various endotypes of childhood allergic diseases using an integrative multi-omics approach are underway. The ECHO-COCOA study will evolve further in the future by increasing its sample size, using advanced exposure measurement methods, integrating different omics technologies, and developing new statistical methods. Collaboration and integration with other birth cohort studies or external validation will aid in advancing the ECHO-COCOA study.

Conclusions

The findings of this study may enable the development of precision medicine and prevention of allergic diseases, obesity, and neurodevelopment based on harmful exposures, especially during critical periods of life.

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.