肺癌和心血管疾病

IF 12.8 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Jacc: Cardiooncology Pub Date : 2025-06-01 DOI:10.1016/j.jaccao.2025.05.003

Malak El-Rayes MD , Inbar Nardi Agmon MD, MPH , Christopher Yu MBBS, PhD , Nichanan Osataphan MD, PhD , Helena A. Yu MD , Andrew Hope MD , Adrian Sacher MD , Anthony F. Yu MD, MS , Husam Abdel-Qadir MD, PhD , Paaladinesh Thavendiranathan MD, SM

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引用次数: 0

摘要

在癌症患者中，肺癌患者既往心血管疾病（CVD）患病率最高，诊断后心血管事件风险最高。这是由共同的风险因素驱动的，特别是吸烟和社会经济因素，以及共同的生物学。此外，肺癌的多模式治疗，包括手术、放疗、化疗、免疫治疗和靶向治疗，都与CVD有关。肺癌的预防、筛查和治疗的改进提高了癌症生存率，增加了心血管疾病与总体生存率和生活质量的相关性。本文综述了肺癌及其治疗，并讨论了CVD的驱动因素、风险评估、监测、预防和治疗策略。

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Lung Cancer and Cardiovascular Disease

Among patients with cancer, those with lung cancer have the highest prevalence of pre-existing cardiovascular disease (CVD) and the highest risk of cardiovascular events postdiagnosis. This is driven by shared risk factors, particularly smoking and socioeconomic factors, and common biology. Furthermore, multimodality therapies for lung cancer, including surgery, radiation, chemotherapy, immunotherapy, and targeted therapy, are associated with CVD. Improvements in prevention, screening, and therapy for lung cancer have led to improved cancer survival, increasing the relevance of CVD for overall survival and quality of life. This review provides an overview of lung cancer and its treatment and discusses drivers of CVD, risk assessment, surveillance, prevention, and treatment strategies.

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来源期刊

Jacc: Cardiooncology Multiple-

CiteScore

12.50

自引率

6.30%

发文量

106

期刊介绍： JACC: CardioOncology is a specialized journal that belongs to the esteemed Journal of the American College of Cardiology (JACC) family. Its purpose is to enhance cardiovascular care for cancer patients by publishing high-quality, innovative scientific research and sharing evidence-based knowledge. The journal aims to revolutionize the field of cardio-oncology and actively involve and educate professionals in both cardiovascular and oncology fields. It covers a wide range of topics including pre-clinical, translational, and clinical research, as well as best practices in cardio-oncology. Key areas of focus include understanding disease mechanisms, utilizing in vitro and in vivo models, exploring novel and traditional therapeutics (across Phase I-IV trials), studying epidemiology, employing precision medicine, and investigating primary and secondary prevention. Amyloidosis, cardiovascular risk factors, heart failure, and vascular disease are some examples of the disease states that are of particular interest to the journal. However, it welcomes research on other relevant conditions as well.