原发性皮肤去分化和未分化黑色素瘤

IF 3.5 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Ingrid Ferreira , Thomas Brenn
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引用次数: 0

摘要

由于其广泛的临床、组织病理学和分子光谱,黑色素瘤的诊断仍然具有挑战性。虽然黑素瘤通过免疫组织化学通常表现为黑素细胞表型,但在罕见的情况下,黑素细胞分化的常规标记物(如S100、SOX10、Melan a和HMB45)可能没有染色。这种现象最常见于转移性黑色素瘤,但也越来越多地被认为是原发性皮肤和粘膜黑色素瘤。当这些肿瘤出现在传统黑色素瘤前体的背景下,无论是形态学上还是免疫组织化学上,都被称为去分化黑色素瘤。未分化黑色素瘤提出了一个特殊的诊断挑战,因为他们在缺乏可识别的黑色素瘤前体成分。本文概述了这些罕见肿瘤的临床,组织病理学和分子特征,以促进识别,并允许更自信的诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Primary cutaneous dedifferentiated and undifferentiated melanoma
The diagnosis of melanoma remains challenging due to its wide clinical, histopathologic and molecular spectrum. While melanomas typically display a melanocytic phenotype by immunohistochemistry, staining for the conventional markers of melanocytic differentiation (e.g. S100, SOX10, Melan A and HMB45) may be absent in rare instances. This phenomenon is most frequently encountered in the metastatic setting but is increasingly recognized also in primary cutaneous and mucosal melanomas. These tumors are referred to as dedifferentiated melanoma when arising in the background of a conventional melanoma precursor, either morphologically or by immunohistochemistry. Undifferentiated melanomas pose a particular diagnostic challenge as they present in the absence of a recognizable melanoma precursor component. This manuscript outlines the clinical, histopathological and molecular features of these rare tumors to facilitate recognition and allow for more confident diagnosis.
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来源期刊
CiteScore
4.80
自引率
0.00%
发文量
69
审稿时长
71 days
期刊介绍: Each issue of Seminars in Diagnostic Pathology offers current, authoritative reviews of topics in diagnostic anatomic pathology. The Seminars is of interest to pathologists, clinical investigators and physicians in practice.
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