经口内窥镜甲状腺切除术前庭入路治疗pT1b乳头状甲状腺癌：手术和肿瘤结果

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-06-17 DOI:10.1016/j.oraloncology.2025.107406

Duy Quoc Ngo , Du Sy Truong , Duong The Le , Thang Manh Hoang

{"title":"经口内窥镜甲状腺切除术前庭入路治疗pT1b乳头状甲状腺癌：手术和肿瘤结果","authors":"Duy Quoc Ngo , Du Sy Truong , Duong The Le , Thang Manh Hoang","doi":"10.1016/j.oraloncology.2025.107406","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Evidence regarding efficacy and oncological safety of Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) for papillary thyroid carcinoma (PTC) with tumor size 1–2 cm remains limited. This study evaluates the surgical and oncological outcomes of TOETVA in patients with pT1b PTC.</div></div><div><h3>Methods</h3><div>We conducted a cohort study of 50 consecutive patients with pT1b PTC who underwent TOETVA between January 2019 and December 2024 at Our Hospital. Clinical characteristics, surgical outcomes, and long-term oncological results were evaluated. All procedures were performed by a single experienced endoscopic surgeon. Patients were followed for recurrence and complications.</div></div><div><h3>Results</h3><div>The cohort comprised predominantly female patients (96 %) with mean age 30.5 ± 7.1 years. Mean tumor size was 17 ± 4.6 mm. Lobectomy with isthmusectomy and central neck dissection was performed in 44 patients (88 %) with mean operative time of 85.4 ± 7.5 min, while total thyroidectomy with central neck dissection was performed in 6 patients (12 %) with mean operative time of 122.5 ± 5.2 min. Occult central lymph node metastases were identified in 15 patients (30 %). Mean lymph node yield was 4.2 ± 2.2 nodes. Temporary mental nerve injury occurred in 2 patients (4.0 %) and temporary recurrent laryngeal nerve palsy in 2 patients (4.0 %), all resolving within 3 months. No permanent complications were observed. During mean follow-up of 29.6 months (range 2.4–64.4), no recurrences were detected, and all patients reported satisfactory cosmetic outcomes.</div></div><div><h3>Conclusions</h3><div>TOETVA represents a safe and effective approach for managing pT1b PTC, demonstrating excellent surgical outcomes and patient satisfaction with minimal complications.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"167 ","pages":"Article 107406"},"PeriodicalIF":4.0000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transoral endoscopic thyroidectomy vestibular approach for pT1b papillary thyroid carcinoma: surgical and oncological outcomes\",\"authors\":\"Duy Quoc Ngo , Du Sy Truong , Duong The Le , Thang Manh Hoang\",\"doi\":\"10.1016/j.oraloncology.2025.107406\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Evidence regarding efficacy and oncological safety of Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) for papillary thyroid carcinoma (PTC) with tumor size 1–2 cm remains limited. This study evaluates the surgical and oncological outcomes of TOETVA in patients with pT1b PTC.</div></div><div><h3>Methods</h3><div>We conducted a cohort study of 50 consecutive patients with pT1b PTC who underwent TOETVA between January 2019 and December 2024 at Our Hospital. Clinical characteristics, surgical outcomes, and long-term oncological results were evaluated. All procedures were performed by a single experienced endoscopic surgeon. Patients were followed for recurrence and complications.</div></div><div><h3>Results</h3><div>The cohort comprised predominantly female patients (96 %) with mean age 30.5 ± 7.1 years. Mean tumor size was 17 ± 4.6 mm. Lobectomy with isthmusectomy and central neck dissection was performed in 44 patients (88 %) with mean operative time of 85.4 ± 7.5 min, while total thyroidectomy with central neck dissection was performed in 6 patients (12 %) with mean operative time of 122.5 ± 5.2 min. Occult central lymph node metastases were identified in 15 patients (30 %). Mean lymph node yield was 4.2 ± 2.2 nodes. Temporary mental nerve injury occurred in 2 patients (4.0 %) and temporary recurrent laryngeal nerve palsy in 2 patients (4.0 %), all resolving within 3 months. No permanent complications were observed. During mean follow-up of 29.6 months (range 2.4–64.4), no recurrences were detected, and all patients reported satisfactory cosmetic outcomes.</div></div><div><h3>Conclusions</h3><div>TOETVA represents a safe and effective approach for managing pT1b PTC, demonstrating excellent surgical outcomes and patient satisfaction with minimal complications.</div></div>\",\"PeriodicalId\":19716,\"journal\":{\"name\":\"Oral oncology\",\"volume\":\"167 \",\"pages\":\"Article 107406\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oral oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1368837525002350\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral oncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1368837525002350","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

摘要

目的经口内窥镜甲状腺切除术前庭入路（TOETVA）治疗肿瘤大小为1-2 cm的乳头状甲状腺癌（PTC）的疗效和肿瘤安全性的证据仍然有限。本研究评估pT1b型PTC患者TOETVA的手术和肿瘤预后。方法：我们对2019年1月至2024年12月在我院连续接受TOETVA治疗的50例pT1b PTC患者进行了队列研究。评估临床特征、手术结果和长期肿瘤结果。所有手术均由一位经验丰富的内窥镜外科医生完成。随访患者的复发及并发症情况。结果以女性患者为主（96%），平均年龄30.5±7.1岁。平均肿瘤大小为17±4.6 mm。行肺叶切除+峡部切除+中央颈清扫44例（88%），平均手术时间85.4±7.5 min；行甲状腺全切除术+中央颈清扫6例（12%），平均手术时间122.5±5.2 min。15例（30%）发现隐匿性中央淋巴结转移。平均淋巴结清扫量为4.2±2.2个。暂时性精神神经损伤2例（4.0%），暂时性喉返神经麻痹2例（4.0%），均在3个月内痊愈。无永久性并发症。在平均29.6个月（2.4-64.4）的随访期间，无复发，所有患者均报告满意的美容效果。结论etva是一种安全有效的治疗pT1b PTC的方法，具有良好的手术效果和患者满意度，并发症最少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Transoral endoscopic thyroidectomy vestibular approach for pT1b papillary thyroid carcinoma: surgical and oncological outcomes

Objectives

Evidence regarding efficacy and oncological safety of Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) for papillary thyroid carcinoma (PTC) with tumor size 1–2 cm remains limited. This study evaluates the surgical and oncological outcomes of TOETVA in patients with pT1b PTC.

Methods

We conducted a cohort study of 50 consecutive patients with pT1b PTC who underwent TOETVA between January 2019 and December 2024 at Our Hospital. Clinical characteristics, surgical outcomes, and long-term oncological results were evaluated. All procedures were performed by a single experienced endoscopic surgeon. Patients were followed for recurrence and complications.

Results

The cohort comprised predominantly female patients (96 %) with mean age 30.5 ± 7.1 years. Mean tumor size was 17 ± 4.6 mm. Lobectomy with isthmusectomy and central neck dissection was performed in 44 patients (88 %) with mean operative time of 85.4 ± 7.5 min, while total thyroidectomy with central neck dissection was performed in 6 patients (12 %) with mean operative time of 122.5 ± 5.2 min. Occult central lymph node metastases were identified in 15 patients (30 %). Mean lymph node yield was 4.2 ± 2.2 nodes. Temporary mental nerve injury occurred in 2 patients (4.0 %) and temporary recurrent laryngeal nerve palsy in 2 patients (4.0 %), all resolving within 3 months. No permanent complications were observed. During mean follow-up of 29.6 months (range 2.4–64.4), no recurrences were detected, and all patients reported satisfactory cosmetic outcomes.

Conclusions

TOETVA represents a safe and effective approach for managing pT1b PTC, demonstrating excellent surgical outcomes and patient satisfaction with minimal complications.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.