无症状/亚显微间日疟原虫感染：预防疟疾传播重新建立的潜在挑战的系统综述和meta分析

IF 2.4 Q3 INFECTIOUS DISEASES

Parasite Epidemiology and Control Pub Date : 2025-06-15 DOI:10.1016/j.parepi.2025.e00442

Siqi Wang, He Yan, Li Zhang, Zhigui Xia, Jianhai Yin

{"title":"无症状/亚显微间日疟原虫感染：预防疟疾传播重新建立的潜在挑战的系统综述和meta分析","authors":"Siqi Wang, He Yan, Li Zhang, Zhigui Xia, Jianhai Yin","doi":"10.1016/j.parepi.2025.e00442","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div><em>Plasmodium vivax</em> is not only the second most prevalent cause of malaria worldwide, but also the second leading cause of imported malaria in China. This poses a significant threat to preventing the re-establishment of malaria transmission, as the competent vector (<em>Anopheles sinensis</em>) suitable for <em>vivax</em> malaria transmission is widely distributed in China. Particularly, the asymptomatic <em>P. vivax</em> infection as another important source of infection deserves further study, but it is rarely reported.</div></div><div><h3>Methods</h3><div>PubMed, CNKI and Wanfang databases were systematically searched for asymptomatic <em>P. vivax</em> infection relevant studies published between February 2014 and February 2024. I-squared statistics (<em>I</em><sup>2</sup>) was used to assess heterogeneity among included studies. The pooled prevalence and pooled odds ratio and their corresponding 95 % Confidence Interval were estimated using the random effects model in Review Manager 5.4 software.</div></div><div><h3>Results</h3><div>Seventy-one eligible studies were included in this analysis. Both study countries (<em>P</em> < 0.001, <em>I</em><sup>2</sup> = 95 %) and diagnostic methods (<em>P</em> = 0.001, <em>I</em><sup>2</sup> = 95 %) were the source of heterogeneity. The rates of asymptomatic malaria infection detected by the gold standard method of microscopy in the countries from Africa, Asia, Oceania and Americas were 9.2 %, 4.8 %, 15.6 % and 14.5 %, respectively. And the corresponding rates of asymptomatic <em>P. vivax</em> infection were 4.0 %, 2.1 %, 10.6 % and 13.0 %. In terms of diagnostic methods, the rate of asymptomatic <em>P. vivax</em> infection (5.6 %) detected by polymerase chain reaction in the population was the highest (<em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>According to the asymptomatic <em>P. vivax</em> infection worldwide, the countries with the higher rate of asymptomatic infection are the main source of <em>vivax</em> malaria cases imported into China, which indicates a potentially higher potential risk of importation of asymptomatic <em>P. vivax</em> infection. Therefore, it is necessary to develop more sensitive, easier to operate, and more cost-effective techniques to detect and screen asymptomatic malaria infections in a timely manner, so as to prevent re-establishment of malaria transmission.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"30 ","pages":"Article e00442"},"PeriodicalIF":2.4000,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Asymptomatic/submicroscopic Plasmodium vivax infection: A systematic review and META-analysis on the hidden challenge for preventing re-establishment of malaria transmission\",\"authors\":\"Siqi Wang, He Yan, Li Zhang, Zhigui Xia, Jianhai Yin\",\"doi\":\"10.1016/j.parepi.2025.e00442\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div><em>Plasmodium vivax</em> is not only the second most prevalent cause of malaria worldwide, but also the second leading cause of imported malaria in China. This poses a significant threat to preventing the re-establishment of malaria transmission, as the competent vector (<em>Anopheles sinensis</em>) suitable for <em>vivax</em> malaria transmission is widely distributed in China. Particularly, the asymptomatic <em>P. vivax</em> infection as another important source of infection deserves further study, but it is rarely reported.</div></div><div><h3>Methods</h3><div>PubMed, CNKI and Wanfang databases were systematically searched for asymptomatic <em>P. vivax</em> infection relevant studies published between February 2014 and February 2024. I-squared statistics (<em>I</em><sup>2</sup>) was used to assess heterogeneity among included studies. The pooled prevalence and pooled odds ratio and their corresponding 95 % Confidence Interval were estimated using the random effects model in Review Manager 5.4 software.</div></div><div><h3>Results</h3><div>Seventy-one eligible studies were included in this analysis. Both study countries (<em>P</em> < 0.001, <em>I</em><sup>2</sup> = 95 %) and diagnostic methods (<em>P</em> = 0.001, <em>I</em><sup>2</sup> = 95 %) were the source of heterogeneity. The rates of asymptomatic malaria infection detected by the gold standard method of microscopy in the countries from Africa, Asia, Oceania and Americas were 9.2 %, 4.8 %, 15.6 % and 14.5 %, respectively. And the corresponding rates of asymptomatic <em>P. vivax</em> infection were 4.0 %, 2.1 %, 10.6 % and 13.0 %. In terms of diagnostic methods, the rate of asymptomatic <em>P. vivax</em> infection (5.6 %) detected by polymerase chain reaction in the population was the highest (<em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>According to the asymptomatic <em>P. vivax</em> infection worldwide, the countries with the higher rate of asymptomatic infection are the main source of <em>vivax</em> malaria cases imported into China, which indicates a potentially higher potential risk of importation of asymptomatic <em>P. vivax</em> infection. Therefore, it is necessary to develop more sensitive, easier to operate, and more cost-effective techniques to detect and screen asymptomatic malaria infections in a timely manner, so as to prevent re-establishment of malaria transmission.</div></div>\",\"PeriodicalId\":37873,\"journal\":{\"name\":\"Parasite Epidemiology and Control\",\"volume\":\"30 \",\"pages\":\"Article e00442\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parasite Epidemiology and Control\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405673125000352\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasite Epidemiology and Control","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405673125000352","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

间日疟原虫是全球第二大疟疾流行病因，也是中国输入性疟疾的第二大病因。由于适合间日疟疾传播的中华按蚊（Anopheles sinensis）在中国广泛分布，这对预防疟疾传播的重新建立构成了重大威胁。特别是无症状间日疟原虫感染作为另一重要感染源值得进一步研究，但鲜有报道。方法系统检索spubmed、中国知网和万方数据库2014年2月至2024年2月发表的无症状间日疟原虫感染相关研究。采用i平方统计（I2）来评估纳入研究之间的异质性。使用Review Manager 5.4软件中的随机效应模型估计合并患病率和合并优势比及其相应的95%置信区间。结果纳入71项符合条件的研究。两个研究国家(P <；0.001, I2 = 95%)和诊断方法（P = 0.001, I2 = 95%）是异质性的来源。非洲、亚洲、大洋洲和美洲国家显微镜金标准法无症状疟疾检出率分别为9.2%、4.8%、15.6%和14.5%。无症状间日疟原虫感染率分别为4.0%、2.1%、10.6%和13.0%。从诊断方法上看，人群中无症状间日疟原虫感染率以聚合酶链反应检出率（5.6%）最高(P <；0.001)。结论从全球无症状间日疟感染情况来看，无症状感染率较高的国家是中国输入性间日疟病例的主要来源，提示无症状间日疟输入的潜在风险较高。因此，有必要开发更灵敏、更易于操作、更具成本效益的技术，及时发现和筛查无症状疟疾感染，以防止疟疾传播的重新建立。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Asymptomatic/submicroscopic Plasmodium vivax infection: A systematic review and META-analysis on the hidden challenge for preventing re-establishment of malaria transmission

Background

Plasmodium vivax is not only the second most prevalent cause of malaria worldwide, but also the second leading cause of imported malaria in China. This poses a significant threat to preventing the re-establishment of malaria transmission, as the competent vector (Anopheles sinensis) suitable for vivax malaria transmission is widely distributed in China. Particularly, the asymptomatic P. vivax infection as another important source of infection deserves further study, but it is rarely reported.

Methods

PubMed, CNKI and Wanfang databases were systematically searched for asymptomatic P. vivax infection relevant studies published between February 2014 and February 2024. I-squared statistics (I²) was used to assess heterogeneity among included studies. The pooled prevalence and pooled odds ratio and their corresponding 95 % Confidence Interval were estimated using the random effects model in Review Manager 5.4 software.

Results

Seventy-one eligible studies were included in this analysis. Both study countries (P < 0.001, I² = 95 %) and diagnostic methods (P = 0.001, I² = 95 %) were the source of heterogeneity. The rates of asymptomatic malaria infection detected by the gold standard method of microscopy in the countries from Africa, Asia, Oceania and Americas were 9.2 %, 4.8 %, 15.6 % and 14.5 %, respectively. And the corresponding rates of asymptomatic P. vivax infection were 4.0 %, 2.1 %, 10.6 % and 13.0 %. In terms of diagnostic methods, the rate of asymptomatic P. vivax infection (5.6 %) detected by polymerase chain reaction in the population was the highest (P < 0.001).

Conclusion

According to the asymptomatic P. vivax infection worldwide, the countries with the higher rate of asymptomatic infection are the main source of vivax malaria cases imported into China, which indicates a potentially higher potential risk of importation of asymptomatic P. vivax infection. Therefore, it is necessary to develop more sensitive, easier to operate, and more cost-effective techniques to detect and screen asymptomatic malaria infections in a timely manner, so as to prevent re-establishment of malaria transmission.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Parasite Epidemiology and Control Medicine-Infectious Diseases

CiteScore

5.70

自引率

3.10%

发文量

审稿时长

17 weeks

期刊介绍： Parasite Epidemiology and Control is an Open Access journal. There is an increasing amount of research in the parasitology area that analyses the patterns, causes, and effects of health and disease conditions in defined populations. This epidemiology of parasite infectious diseases is predominantly studied in human populations but also spans other major hosts of parasitic infections and as such this journal will have a broad remit. We will focus on the major areas of epidemiological study including disease etiology, disease surveillance, drug resistance and geographical spread and screening, biomonitoring, and comparisons of treatment effects in clinical trials for both human and other animals. We will also look at the epidemiology and control of vector insects. The journal will also cover the use of geographic information systems (Epi-GIS) for epidemiological surveillance which is a rapidly growing area of research in infectious diseases. Molecular epidemiological approaches are also particularly encouraged.