腙的电化学宝石-双芳基化：获得双（吲哚基）甲烷

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-06-17 DOI:10.1002/ejoc.202500515

Hui Meng, Jing Feng, Mingqi Yang, Mingming Yu, Zefeng Xu, Chuanying Li

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引用次数: 0

摘要

提出了一种以腙和吲哚为原料直接合成双（吲哚基）甲烷衍生物的电化学有机方法。该方法对脂肪族、芳香族和杂芳香族醛有效，可与一系列富电子和贫电子吲哚反应，以优异的收率生成所需的BIMs。此外，在电流的作用下，多种吲哚衍生物也成功合成了潜在的抗肥胖药物，bim的转化证明了该方案的应用潜力。

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Electrochemical gem-Bisarylation of Hydrazone: Access to Bis(indolyl)methane

An electrochemical organic method for the direct synthesis of bis(indolyl)methane derivatives is presented, with the reaction of hydrazones and indoles. This developed approach is effective for aliphatic, aromatic, and heteroaromatic aldehydes, which react with a range of electron-rich and electron-poor indoles to produce the desired BIMs in good to excellent yields. Additionally, potential antiobesity drug was also successfully synthesized with various indole derivatives under the influence of an electric current, and the transformation of BIMs demonstrated the application potential of this protocol.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.