小鼠感觉神经节的基因表达分析确定了NGF/TrkA在膝关节骨关节炎慢性化中的关键作用

IF 7.2 2区医学 Q1 ORTHOPEDICS

Osteoarthritis and Cartilage Pub Date : 2025-06-15 DOI:10.1016/j.joca.2025.06.004

Daniel Cañada-García, Laura Calvo-Enrique, Silvia Lisa, Joao Sousa-Valente, Marta López-García, Ivan Arisi, Mara D’Onofrío, Carlos Prieto, Juan Carlos Arévalo

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引用次数: 0

摘要

单碘乙酸酯（MIA）可实验性诱导小鼠膝囊骨关节炎（OA）。我们的目的是评估NGF/TrkA轴在OA中的作用，鉴定MIA注射后WT和超敏TrkAP782S （KI）小鼠膝神经支配背根神经节（DRG）中的差异表达基因（DEGs）和功能通路。

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Gene expression analyses in mouse sensory ganglia determine a crucial role of NGF/TrkA in knee osteoarthritis chronification

Osteoarthritis (OA) can be experimentally induced by injecting mono-iodoacetate (MIA) in the knee capsule of mice. Our aim was to assess the role of NGF/TrkA axis in OA identifying differentially expressed genes (DEGs) and functional pathways in knee-innervating dorsal root ganglia (DRG) from WT and hypersensitive TrkAP782S (KI) mice after MIA injection.

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来源期刊

Osteoarthritis and Cartilage 医学-风湿病学

CiteScore

11.70

自引率

7.10%

发文量

802

审稿时长

52 days

期刊介绍： Osteoarthritis and Cartilage is the official journal of the Osteoarthritis Research Society International. It is an international, multidisciplinary journal that disseminates information for the many kinds of specialists and practitioners concerned with osteoarthritis.