近红外光下不同形态NH2-MIL-101(Fe)@Ag对细菌的清除作用

IF 7.2 2区材料科学 Q2 CHEMISTRY, PHYSICAL

Chemistry of Materials Pub Date : 2025-06-17 DOI:10.1021/acs.chemmater.5c00958

Dan Zhao, Wenjie Jiang, Wang Zhang, Chenhao Zhang, Wenjun Zhao, Zhizhou Chen, Yanan Liu, Jiajie Xu

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引用次数: 0

摘要

抗生素的过度使用导致了耐药细菌和超级细菌，需要采取紧急策略。mof虽然是潜在的抗微生物载体，但在低剂量和单次治疗中存在局限性。通过在前驱体溶液中加入不同量的CTAB，得到了两种不同形态的NH2-MIL-101(Fe)@Ag纳米试剂，即NH2-MIL-101(Fe)@Ag-1（立方体）和NH2-MIL-101(Fe)@Ag-2（八面体）。抗菌实验表明，这两种具有光热和光动力效应的纳米试剂对高浓度金黄色葡萄球菌和大肠杆菌（107 CFU/mL）在15 min内的杀菌率接近100%。Ag离子和高温共同作用，使细胞内蛋白失活和细胞膜破坏，使NH2-MIL-101(Fe)@Ag在八面体中达到100%，在低温下表现出持久而优越的杀菌性能剂量（64 μg/mL），明显优于其他抗菌试剂。并通过离散傅立叶变换（DFT）计算详细讨论了增强机理。在880 nm近红外照射下，Ag与NH2-MIL-101 （Fe）之间发生了特殊的电子转移过程，促进了ROS的生成，增强了抗菌效果。此外，由于银离子和光热效应，这两种纳米试剂在体内对伤口愈合具有良好的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Near-Infrared Light-Triggered Bacterial Eradication by Different Morphologies of NH2-MIL-101(Fe)@Ag

查看原文本刊更多论文

Near-Infrared Light-Triggered Bacterial Eradication by Different Morphologies of NH2-MIL-101(Fe)@Ag

Antibiotic overuse has led to drug-resistant bacteria and superbugs, necessitating urgent strategies. MOFs, although they are potential antimicrobial carriers, have limitations at low doses and in single therapy. Here, by adding different amounts of CTAB in the precursor solution, two different morphologies of NH₂-MIL-101(Fe)@Ag nanoagents were obtained, namely, NH₂-MIL-101(Fe)@Ag-1 (Cube) and NH₂-MIL-101(Fe)@Ag-2 (Octahedron). Antibacterial experiments showed that these two nano reagents with both photothermal and photodynamic effects exhibited nearly 100% bactericidal rate against high concentrations of Staphylococcus aureus and Escherichia coli (10⁷ CFU/mL) within 15 min. The combination of inactivation of intracellular proteins and disruption of cell membranes induced by Ag ions and high temperature resulted in NH₂-MIL-101(Fe)@Ag 100% in an octahedron showing durable and superior bactericidal performance at low doses (64 μg/mL), which is much better than other antibacterial reagents. Furthermore, the enhanced mechanism was discussed in detail by DFT calculations. A special electron transfer process occurred between Ag and NH₂-MIL-101 (Fe) under 880 nm NIR irradiation, which promoted the generation of ROS and enhanced the antibacterial effect. In addition, these two nano reagents have good therapeutic effects on wound healing in vivo due to silver ions and photothermal effects.

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来源期刊

Chemistry of Materials 工程技术-材料科学：综合

CiteScore

14.10

自引率

5.80%

发文量

929

审稿时长

1.5 months

期刊介绍： The journal Chemistry of Materials focuses on publishing original research at the intersection of materials science and chemistry. The studies published in the journal involve chemistry as a prominent component and explore topics such as the design, synthesis, characterization, processing, understanding, and application of functional or potentially functional materials. The journal covers various areas of interest, including inorganic and organic solid-state chemistry, nanomaterials, biomaterials, thin films and polymers, and composite/hybrid materials. The journal particularly seeks papers that highlight the creation or development of innovative materials with novel optical, electrical, magnetic, catalytic, or mechanical properties. It is essential that manuscripts on these topics have a primary focus on the chemistry of materials and represent a significant advancement compared to prior research. Before external reviews are sought, submitted manuscripts undergo a review process by a minimum of two editors to ensure their appropriateness for the journal and the presence of sufficient evidence of a significant advance that will be of broad interest to the materials chemistry community.